Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy
Introduction Study in which we found a significant and specific alteration of eotaxins-3 in active EoE childrens with food allergy. Aim The aim of the study was to identity eotaxin-3 that correlated with activity of EoE as measurmed by esophageal eosinophilia and response to treatment by using e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2017-04-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4424 |
| _version_ | 1818034100587462656 |
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| author | Krystyna Stencel-Gabriel Joanna Kula-Gradzik Łukasz Parszewski Anna Majda |
| author_facet | Krystyna Stencel-Gabriel Joanna Kula-Gradzik Łukasz Parszewski Anna Majda |
| author_sort | Krystyna Stencel-Gabriel |
| collection | DOAJ |
| description | Introduction
Study in which we found a significant and specific alteration of eotaxins-3 in active EoE childrens with food allergy.
Aim
The aim of the study was to identity eotaxin-3 that correlated with activity of EoE as measurmed by esophageal eosinophilia and response to treatment by using elimination diet in children group with food allergy in the course of EoE.
Material and methods
Five childrens ranging in age from 12 to 18 years with EoE and food allergy was studied for up to 12 weeks of used eliminate food to which the children are sensitized. Biomarker (eotaxin-3 / CCL26) in serum were analyzed as to their use as a noninvasive biomarker for the diagnosis and assessment of EoE disease status.
Results
Eotaxin-3 levels correlated significantly with all investigated clinical parameters: blood eosinophils levels ( r=0,80,p<0,01), eosinophils in thissue biopsy ( r=0,66, p<0,01) and IgE levels (r=0,34,p<0,05) from EoE patients.
Conclusions
Eotaxin-3 might constitute a pathogenic player in tissue eosinophilia and subsequent esophagus damage, and a biomarker for disease activity and interesting therapeutic target in EoE. |
| first_indexed | 2024-12-10T06:33:48Z |
| format | Article |
| id | doaj.art-31878381456f42cfaf6674bfd0053148 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-10T06:33:48Z |
| publishDate | 2017-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-31878381456f42cfaf6674bfd00531482022-12-22T01:59:00ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062017-04-0175112310.5281/zenodo.5693304208Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergyKrystyna Stencel-Gabriel0Joanna Kula-Gradzik1Łukasz Parszewski2Anna Majda3Department of Pediatric, SUM, KatowiceDepartment of Pediatric, SUM, KatowiceMedical Center Darmed , Bielsko BialaDepartment of Pediatric, SUM, KatowiceIntroduction Study in which we found a significant and specific alteration of eotaxins-3 in active EoE childrens with food allergy. Aim The aim of the study was to identity eotaxin-3 that correlated with activity of EoE as measurmed by esophageal eosinophilia and response to treatment by using elimination diet in children group with food allergy in the course of EoE. Material and methods Five childrens ranging in age from 12 to 18 years with EoE and food allergy was studied for up to 12 weeks of used eliminate food to which the children are sensitized. Biomarker (eotaxin-3 / CCL26) in serum were analyzed as to their use as a noninvasive biomarker for the diagnosis and assessment of EoE disease status. Results Eotaxin-3 levels correlated significantly with all investigated clinical parameters: blood eosinophils levels ( r=0,80,p<0,01), eosinophils in thissue biopsy ( r=0,66, p<0,01) and IgE levels (r=0,34,p<0,05) from EoE patients. Conclusions Eotaxin-3 might constitute a pathogenic player in tissue eosinophilia and subsequent esophagus damage, and a biomarker for disease activity and interesting therapeutic target in EoE.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4424eotaxin-3/ccl26, children, food allergy, serum, eosinophilic esophagitis eoe |
| spellingShingle | Krystyna Stencel-Gabriel Joanna Kula-Gradzik Łukasz Parszewski Anna Majda Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy Journal of Education, Health and Sport eotaxin-3/ccl26, children, food allergy, serum, eosinophilic esophagitis eoe |
| title | Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy |
| title_full | Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy |
| title_fullStr | Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy |
| title_full_unstemmed | Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy |
| title_short | Levels of eotaxin-3 as a noninvasive biomarker for monitoring the treatment EoE in school age children with food allergy |
| title_sort | levels of eotaxin 3 as a noninvasive biomarker for monitoring the treatment eoe in school age children with food allergy |
| topic | eotaxin-3/ccl26, children, food allergy, serum, eosinophilic esophagitis eoe |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/4424 |
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