Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, prov...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/11/2641 |
| _version_ | 1797458025003352064 |
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| author | Mariia Stepanova Alexey Nikiforov Tatiana Tennikova Evgenia Korzhikova-Vlakh |
| author_facet | Mariia Stepanova Alexey Nikiforov Tatiana Tennikova Evgenia Korzhikova-Vlakh |
| author_sort | Mariia Stepanova |
| collection | DOAJ |
| description | Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized. |
| first_indexed | 2024-03-09T16:31:10Z |
| format | Article |
| id | doaj.art-3187d97a07c64a73b0b54a57e741fe33 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T16:31:10Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3187d97a07c64a73b0b54a57e741fe332023-11-24T15:01:14ZengMDPI AGPharmaceutics1999-49232023-11-011511264110.3390/pharmaceutics15112641Polypeptide-Based Systems: From Synthesis to Application in Drug DeliveryMariia Stepanova0Alexey Nikiforov1Tatiana Tennikova2Evgenia Korzhikova-Vlakh3Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004 St. Petersburg, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004 St. Petersburg, RussiaInstitute of Chemistry, Saint-Petersburg State University, Universitetskiy pr. 26, Petergof, 198504 St. Petersburg, RussiaInstitute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004 St. Petersburg, RussiaSynthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized.https://www.mdpi.com/1999-4923/15/11/2641polypeptidespolypeptide copolymerspolypeptide particlesself-assemblyhydrogelsdrug delivery systems |
| spellingShingle | Mariia Stepanova Alexey Nikiforov Tatiana Tennikova Evgenia Korzhikova-Vlakh Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery Pharmaceutics polypeptides polypeptide copolymers polypeptide particles self-assembly hydrogels drug delivery systems |
| title | Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery |
| title_full | Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery |
| title_fullStr | Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery |
| title_full_unstemmed | Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery |
| title_short | Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery |
| title_sort | polypeptide based systems from synthesis to application in drug delivery |
| topic | polypeptides polypeptide copolymers polypeptide particles self-assembly hydrogels drug delivery systems |
| url | https://www.mdpi.com/1999-4923/15/11/2641 |
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