The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art
It has been widely acknowledged that modulation of chromatin structure at the promoter region influences the usage of factor binding sites and thus provides first, important level of transcriptional regulation. Chromatin-remodelling complexes utilize the energy of ATP hydrolysis to disassemble nucl...
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| Format: | Article |
| Language: | English |
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University of Zagreb Faculty of Food Technology and Biotechnology
2014-01-01
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| Series: | Food Technology and Biotechnology |
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| Online Access: | http://hrcak.srce.hr/file/175195 |
| _version_ | 1827614297388220416 |
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| author | Slobodan Barbarić |
| author_facet | Slobodan Barbarić |
| author_sort | Slobodan Barbarić |
| collection | DOAJ |
| description | It has been widely acknowledged that modulation of chromatin structure at the promoter region influences the usage of factor binding sites and thus provides first, important level of transcriptional regulation. Chromatin-remodelling complexes utilize the energy of
ATP hydrolysis to disassemble nucleosomes, and their functions are prominently correlated with promoter activation and also repression. Mechanistic details of individual steps and their orchestration in complex remodelling events, as well as regulatory mechanisms controlling remodeller activity, are subjects of current and future studies. The yeast PHO5 promoter was the first and still is one of the best characterized examples of a massive chromatin transition associated with transcriptional activation. Studies with this promoter
provided several breakthrough findings and established basic principles of chromatin-remodelling process. Recent studies have revealed a network of five remodellers from all four remodeller subfamilies involved in this chromatin transition. Importantly, requirement for chromatin remodellers at the PHO8 as well as at PHO84 promoter, activated by the same transactivator as PHO5, are rather different. All these findings point out that chromatin remodelling process is in general even more complex than presumed, and it could be expected that further studies with the well-established PHO promoter system will be rather valuable for its further understanding. |
| first_indexed | 2024-03-09T08:52:53Z |
| format | Article |
| id | doaj.art-318ad5a2dbd3481388ed08a1546b7c56 |
| institution | Directory Open Access Journal |
| issn | 1330-9862 1334-2606 |
| language | English |
| last_indexed | 2024-03-09T08:52:53Z |
| publishDate | 2014-01-01 |
| publisher | University of Zagreb Faculty of Food Technology and Biotechnology |
| record_format | Article |
| series | Food Technology and Biotechnology |
| spelling | doaj.art-318ad5a2dbd3481388ed08a1546b7c562023-12-02T13:48:04ZengUniversity of Zagreb Faculty of Food Technology and BiotechnologyFood Technology and Biotechnology1330-98621334-26062014-01-0152137The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the ArtSlobodan Barbarić0Laboratory of Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, HR-10000 Zagreb, CroatiaIt has been widely acknowledged that modulation of chromatin structure at the promoter region influences the usage of factor binding sites and thus provides first, important level of transcriptional regulation. Chromatin-remodelling complexes utilize the energy of ATP hydrolysis to disassemble nucleosomes, and their functions are prominently correlated with promoter activation and also repression. Mechanistic details of individual steps and their orchestration in complex remodelling events, as well as regulatory mechanisms controlling remodeller activity, are subjects of current and future studies. The yeast PHO5 promoter was the first and still is one of the best characterized examples of a massive chromatin transition associated with transcriptional activation. Studies with this promoter provided several breakthrough findings and established basic principles of chromatin-remodelling process. Recent studies have revealed a network of five remodellers from all four remodeller subfamilies involved in this chromatin transition. Importantly, requirement for chromatin remodellers at the PHO8 as well as at PHO84 promoter, activated by the same transactivator as PHO5, are rather different. All these findings point out that chromatin remodelling process is in general even more complex than presumed, and it could be expected that further studies with the well-established PHO promoter system will be rather valuable for its further understanding.http://hrcak.srce.hr/file/175195chromatin remodellingPHO genestranscriptional regulationSaccharomyces cerevisiae |
| spellingShingle | Slobodan Barbarić The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art Food Technology and Biotechnology chromatin remodelling PHO genes transcriptional regulation Saccharomyces cerevisiae |
| title | The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art |
| title_full | The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art |
| title_fullStr | The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art |
| title_full_unstemmed | The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art |
| title_short | The Yeast PHO Promoters as Paradigm for Transcriptional Regulation by Chromatin Remodelling: Current State of the Art |
| title_sort | yeast pho promoters as paradigm for transcriptional regulation by chromatin remodelling current state of the art |
| topic | chromatin remodelling PHO genes transcriptional regulation Saccharomyces cerevisiae |
| url | http://hrcak.srce.hr/file/175195 |
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