Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
Background: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-so...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.665584/full |
| _version_ | 1819117713139695616 |
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| author | Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts |
| author_facet | Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts |
| author_sort | Michael Marks |
| collection | DOAJ |
| description | Background: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.Method: New functions were developed to facilitate the use of ODK, Enketo and R in large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.Results: Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.Conclusions: We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards. |
| first_indexed | 2024-12-22T05:37:21Z |
| format | Article |
| id | doaj.art-318cbca4382141ec8ca751f7eedf54df |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-22T05:37:21Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-318cbca4382141ec8ca751f7eedf54df2022-12-21T18:37:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-11-01910.3389/fpubh.2021.665584665584Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODKMichael Marks0Sham Lal1Hannah Brindle2Pierre-Stéphane Gsell3Matthew MacGregor4Callum Stott5Martijn van de Rijdt6Guillermo Gutiérrez Almazor7Suman Golia8Conall Watson9Abdourahamane Diallo10Alhassane Toure11Catherine Houlihan12Patrick Keating13Patrick Keating14Hélène Martin15Ana-Maria Henao Restrepo16Yaw Anokwa17Chrissy H. Roberts18London School of Hygiene & Tropical Medicine, London, United KingdomLondon School of Hygiene & Tropical Medicine, London, United KingdomLondon School of Hygiene & Tropical Medicine, London, United KingdomWorld Health Organization, Geneva, SwitzerlandLondon School of Hygiene & Tropical Medicine, London, United KingdomNafundi LLC, San Diego, CA, United StatesEnketo LLC, Denver, CO, United StatesNafundi LLC, San Diego, CA, United StatesLondon School of Hygiene & Tropical Medicine, London, United KingdomLondon School of Hygiene & Tropical Medicine, London, United KingdomWorld Health Organization, Geneva, SwitzerlandWorld Health Organization, Geneva, SwitzerlandLondon School of Hygiene & Tropical Medicine, London, United KingdomMédecins Sans Frontières UK, London, United KingdomUK Public Health Rapid Support Team, London School of Hygiene & Tropical Medicine, London, United KingdomNafundi LLC, San Diego, CA, United StatesWorld Health Organization, Geneva, SwitzerlandEnketo LLC, Denver, CO, United StatesLondon School of Hygiene & Tropical Medicine, London, United KingdomBackground: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.Method: New functions were developed to facilitate the use of ODK, Enketo and R in large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.Results: Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.Conclusions: We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards.https://www.frontiersin.org/articles/10.3389/fpubh.2021.665584/fullEbolaopen-data-kitopen source softwareelectronic data collectionlow and middle income countries |
| spellingShingle | Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK Frontiers in Public Health Ebola open-data-kit open source software electronic data collection low and middle income countries |
| title | Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK |
| title_full | Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK |
| title_fullStr | Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK |
| title_full_unstemmed | Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK |
| title_short | Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK |
| title_sort | electronic data management for vaccine trials in low resource settings upgrades scalability and impact of odk |
| topic | Ebola open-data-kit open source software electronic data collection low and middle income countries |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.665584/full |
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