Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
The Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to promote replication initiation.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29070-5 |
| _version_ | 1818356281289736192 |
|---|---|
| author | Jiaxuan Cheng Ningning Li Yunjing Huo Shangyu Dang Bik-Kwoon Tye Ning Gao Yuanliang Zhai |
| author_facet | Jiaxuan Cheng Ningning Li Yunjing Huo Shangyu Dang Bik-Kwoon Tye Ning Gao Yuanliang Zhai |
| author_sort | Jiaxuan Cheng |
| collection | DOAJ |
| description | The Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to promote replication initiation. |
| first_indexed | 2024-12-13T19:54:43Z |
| format | Article |
| id | doaj.art-318d92e129594415b0f03782a6a4499e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T19:54:43Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-318d92e129594415b0f03782a6a4499e2022-12-21T23:33:20ZengNature PortfolioNature Communications2041-17232022-03-0113111310.1038/s41467-022-29070-5Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinaseJiaxuan Cheng0Ningning Li1Yunjing Huo2Shangyu Dang3Bik-Kwoon Tye4Ning Gao5Yuanliang Zhai6State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversityState Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversitySchool of Biological Sciences, The University of Hong KongDivision of Life Science, The Hong Kong University of Science & TechnologyInstitute for Advanced Study, The Hong Kong University of Science & TechnologyState Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking UniversitySchool of Biological Sciences, The University of Hong KongThe Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to promote replication initiation.https://doi.org/10.1038/s41467-022-29070-5 |
| spellingShingle | Jiaxuan Cheng Ningning Li Yunjing Huo Shangyu Dang Bik-Kwoon Tye Ning Gao Yuanliang Zhai Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase Nature Communications |
| title | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase |
| title_full | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase |
| title_fullStr | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase |
| title_full_unstemmed | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase |
| title_short | Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase |
| title_sort | structural insight into the mcm double hexamer activation by dbf4 cdc7 kinase |
| url | https://doi.org/10.1038/s41467-022-29070-5 |
| work_keys_str_mv | AT jiaxuancheng structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT ningningli structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT yunjinghuo structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT shangyudang structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT bikkwoontye structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT ninggao structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase AT yuanliangzhai structuralinsightintothemcmdoublehexameractivationbydbf4cdc7kinase |