Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment

Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment

Abstract Background Steroid drugs are essential for disease prevention and clinical treatment. However, due to intricated steroid structure, traditional chemical methods are rarely implemented into the whole synthetic process for generating steroid intermediates. Novel steroid drug precursors and th...

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Bibliographic Details
Main Authors: Chen-Yang Yuan, Zhi-Guo Ma, Jing-Xian Zhang, Xiang-Cen Liu, Gui-Lin Du, Jun-Song Sun, Ji-Ping Shi, Bao-Guo Zhang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Microbial Cell Factories
Subjects:
9,21-dihydroxy-20-methyl-pregna-4-en-3-one (9-OH-4-HP)
kstD
hsd4A
fadA5
Intracellular environment
Online Access:https://doi.org/10.1186/s12934-021-01717-w

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