Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital
Objective: To Identify the occurrence of adverse reactions to medications (ADR) in patients using off-label prescriptions admitted in an adult intensive care unit (ICU). Methods: Cross-sectional and prospective study evaluated the use of off-label medications and the appearance of ADR in an adult c...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2023-03-01
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| Series: | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| Online Access: | https://rbfhss.org.br/sbrafh/article/view/868 |
| _version_ | 1797854652606185472 |
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| author | Lívia P. MOREIRA Marjorie M. GUEDES Eunice B. PERRAUD Arnaldo A. PEIXOTO-JUNIOR Eudiana V. FRANCELINO Marta F. FONTELES |
| author_facet | Lívia P. MOREIRA Marjorie M. GUEDES Eunice B. PERRAUD Arnaldo A. PEIXOTO-JUNIOR Eudiana V. FRANCELINO Marta F. FONTELES |
| author_sort | Lívia P. MOREIRA |
| collection | DOAJ |
| description |
Objective: To Identify the occurrence of adverse reactions to medications (ADR) in patients using off-label prescriptions admitted in an adult intensive care unit (ICU). Methods: Cross-sectional and prospective study evaluated the use of off-label medications and the appearance of ADR in an adult clinical ICU of a Brazilian hospital from March to Aug/2018. The prescriptions were classified as label, off-label, and unlicensed, and the NARANJO algorithm assessed ADR occurrence. The suspected cases of ADR were separated into label and off-label. Results: The prevalence of off-label use was 73.0%, with 73.9% prescribed after admission to the ICU. Regarding the category of off-label use, 23.6% were due to the volume of the diluent. The predominant drug classification was systemic antimicrobials, accounting for 16.8%. The PHD represented 68.7% of the off-label medicines. Sixty suspected ADR were identified in 26 patients registered with suspected ADRs, from that 85.0% resulted from the use of off-label medications. The most prevalent reactions were classified as probable (81.7%), and diarrhoea was the most frequent symptom. There was a significant association between the use of off-label drugs, PHD prescriptions, and the occurrence of ADR (p <0.05).Conclusion: The findings showed that the event of ADR was higher among off-label drugs and PHD prescriptions.
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| first_indexed | 2024-04-09T20:10:41Z |
| format | Article |
| id | doaj.art-318eb20e069f4643b19a0c81d6bae364 |
| institution | Directory Open Access Journal |
| issn | 2179-5924 2316-7750 |
| language | English |
| last_indexed | 2024-04-09T20:10:41Z |
| publishDate | 2023-03-01 |
| publisher | Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| record_format | Article |
| series | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| spelling | doaj.art-318eb20e069f4643b19a0c81d6bae3642023-03-31T23:20:28ZengSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdeRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde2179-59242316-77502023-03-0114110.30968/rbfhss.2023.141.0868Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospitalLívia P. MOREIRAMarjorie M. GUEDESEunice B. PERRAUDArnaldo A. PEIXOTO-JUNIOREudiana V. FRANCELINOMarta F. FONTELES Objective: To Identify the occurrence of adverse reactions to medications (ADR) in patients using off-label prescriptions admitted in an adult intensive care unit (ICU). Methods: Cross-sectional and prospective study evaluated the use of off-label medications and the appearance of ADR in an adult clinical ICU of a Brazilian hospital from March to Aug/2018. The prescriptions were classified as label, off-label, and unlicensed, and the NARANJO algorithm assessed ADR occurrence. The suspected cases of ADR were separated into label and off-label. Results: The prevalence of off-label use was 73.0%, with 73.9% prescribed after admission to the ICU. Regarding the category of off-label use, 23.6% were due to the volume of the diluent. The predominant drug classification was systemic antimicrobials, accounting for 16.8%. The PHD represented 68.7% of the off-label medicines. Sixty suspected ADR were identified in 26 patients registered with suspected ADRs, from that 85.0% resulted from the use of off-label medications. The most prevalent reactions were classified as probable (81.7%), and diarrhoea was the most frequent symptom. There was a significant association between the use of off-label drugs, PHD prescriptions, and the occurrence of ADR (p <0.05).Conclusion: The findings showed that the event of ADR was higher among off-label drugs and PHD prescriptions. https://rbfhss.org.br/sbrafh/article/view/868 |
| spellingShingle | Lívia P. MOREIRA Marjorie M. GUEDES Eunice B. PERRAUD Arnaldo A. PEIXOTO-JUNIOR Eudiana V. FRANCELINO Marta F. FONTELES Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| title | Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital |
| title_full | Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital |
| title_fullStr | Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital |
| title_full_unstemmed | Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital |
| title_short | Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital |
| title_sort | use of off label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a brazilian public hospital |
| url | https://rbfhss.org.br/sbrafh/article/view/868 |
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