Human Virome in Cervix Controlled by the Domination of Human Papillomavirus
Although other co-viral infections could also be considered influencing factors, cervical human papillomavirus (HPV) infection is the main cause of cervical cancer. Metagenomics have been employed in the NGS era to study the microbial community in each habitat. Thus, in this investigation, virome ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/9/2066 |
| _version_ | 1797481301472706560 |
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| author | Thanayod Sasivimolrattana Wasun Chantratita Insee Sensorn Arkom Chaiwongkot Shina Oranratanaphan Parvapan Bhattarakosol |
| author_facet | Thanayod Sasivimolrattana Wasun Chantratita Insee Sensorn Arkom Chaiwongkot Shina Oranratanaphan Parvapan Bhattarakosol |
| author_sort | Thanayod Sasivimolrattana |
| collection | DOAJ |
| description | Although other co-viral infections could also be considered influencing factors, cervical human papillomavirus (HPV) infection is the main cause of cervical cancer. Metagenomics have been employed in the NGS era to study the microbial community in each habitat. Thus, in this investigation, virome capture sequencing was used to examine the virome composition in the HPV-infected cervix. Based on the amount of HPV present in each sample, the results revealed that the cervical virome of HPV-infected individuals could be split into two categories: HPV-dominated (HD; ≥60%) and non-HPV-dominated (NHD; <60%). Cervical samples contained traces of several human viral species, including the molluscum contagiosum virus (MCV), human herpesvirus 4 (HHV4), torque teno virus (TTV), and influenza A virus. When compared to the HD group, the NHD group had a higher abundance of several viruses. Human viral diversity appears to be influenced by HPV dominance. This is the first proof that the diversity of human viruses in the cervix is impacted by HPV abundance. However, more research is required to determine whether human viral variety and the emergence of cancer are related. |
| first_indexed | 2024-03-09T22:12:05Z |
| format | Article |
| id | doaj.art-318f3d134ade4eff8557be43f80e4323 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T22:12:05Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-318f3d134ade4eff8557be43f80e43232023-11-23T19:28:59ZengMDPI AGViruses1999-49152022-09-01149206610.3390/v14092066Human Virome in Cervix Controlled by the Domination of Human PapillomavirusThanayod Sasivimolrattana0Wasun Chantratita1Insee Sensorn2Arkom Chaiwongkot3Shina Oranratanaphan4Parvapan Bhattarakosol5Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok 10330, ThailandCenter for Medical Genomics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandCenter for Medical Genomics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandCenter of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandAlthough other co-viral infections could also be considered influencing factors, cervical human papillomavirus (HPV) infection is the main cause of cervical cancer. Metagenomics have been employed in the NGS era to study the microbial community in each habitat. Thus, in this investigation, virome capture sequencing was used to examine the virome composition in the HPV-infected cervix. Based on the amount of HPV present in each sample, the results revealed that the cervical virome of HPV-infected individuals could be split into two categories: HPV-dominated (HD; ≥60%) and non-HPV-dominated (NHD; <60%). Cervical samples contained traces of several human viral species, including the molluscum contagiosum virus (MCV), human herpesvirus 4 (HHV4), torque teno virus (TTV), and influenza A virus. When compared to the HD group, the NHD group had a higher abundance of several viruses. Human viral diversity appears to be influenced by HPV dominance. This is the first proof that the diversity of human viruses in the cervix is impacted by HPV abundance. However, more research is required to determine whether human viral variety and the emergence of cancer are related.https://www.mdpi.com/1999-4915/14/9/2066viromehuman papillomavirusHPVscervical cancer |
| spellingShingle | Thanayod Sasivimolrattana Wasun Chantratita Insee Sensorn Arkom Chaiwongkot Shina Oranratanaphan Parvapan Bhattarakosol Human Virome in Cervix Controlled by the Domination of Human Papillomavirus Viruses virome human papillomavirus HPVs cervical cancer |
| title | Human Virome in Cervix Controlled by the Domination of Human Papillomavirus |
| title_full | Human Virome in Cervix Controlled by the Domination of Human Papillomavirus |
| title_fullStr | Human Virome in Cervix Controlled by the Domination of Human Papillomavirus |
| title_full_unstemmed | Human Virome in Cervix Controlled by the Domination of Human Papillomavirus |
| title_short | Human Virome in Cervix Controlled by the Domination of Human Papillomavirus |
| title_sort | human virome in cervix controlled by the domination of human papillomavirus |
| topic | virome human papillomavirus HPVs cervical cancer |
| url | https://www.mdpi.com/1999-4915/14/9/2066 |
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