The causal relationship between genetically determined telomere length and meningiomas risk
BackgroundStudies have shown that longer leukocyte telomere length (LTL) is significantly associated with increased risk of meningioma. However, there is limited evidence concerning the causal association of LTL with benign and malignant meningiomas or with the location of benign tumors.MethodsWe us...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178404/full |
| _version_ | 1797737270719021056 |
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| author | Weijie Yu Weijie Yu Yunyun Mei Zhenwei Lu Zhenwei Lu Liwei Zhou Fang Jia Fang Jia Sifang Chen Sifang Chen Zhanxiang Wang Zhanxiang Wang |
| author_facet | Weijie Yu Weijie Yu Yunyun Mei Zhenwei Lu Zhenwei Lu Liwei Zhou Fang Jia Fang Jia Sifang Chen Sifang Chen Zhanxiang Wang Zhanxiang Wang |
| author_sort | Weijie Yu |
| collection | DOAJ |
| description | BackgroundStudies have shown that longer leukocyte telomere length (LTL) is significantly associated with increased risk of meningioma. However, there is limited evidence concerning the causal association of LTL with benign and malignant meningiomas or with the location of benign tumors.MethodsWe used three LTL datasets from different sources, designated by name and sample size as LTL-78592, LTL-9190, and LTL-472174. The linkage disequilibrium score (LDSC) was used to explore the association between LTL and meningioma. We utilized two-sample bidirectional Mendelian randomization (TSMR) to evaluate whether LTL is causally related to meningioma risk. We adjusted for confounders by conducting multivariable Mendelian randomization (MVMR).ResultsIn the LTL-78592, longer LTL was significantly associated with increased risk of malignant [odds ratio (OR) = 5.14, p = 1.04 × 10−5], benign (OR = 4.81, p < 0.05), benign cerebral (OR = 5.36, p < 0.05), and benign unspecified meningioma (OR = 8.26, p < 0.05). The same results were obtained for the LTL-9190. In the LTL-472174, longer LTL was significantly associated with increased risk of malignant (OR = 4.94, p < 0.05), benign (OR = 3.14, p < 0.05), and benign cerebral meningioma (OR = 3.59, p < 0.05). Similar results were obtained in the MVMR. In contrast, only benign cerebral meningioma displayed a possible association with longer LTL (OR = 1.01, p < 0.05). No heterogeneity or horizontal pleiotropy was detected.ConclusionIn brief, genetically predicted longer LTL may increase the risk of benign, malignant, and benign cerebral meningiomas, regardless of the LTL measure, in European populations. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T13:26:14Z |
| publishDate | 2023-08-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-3190e3970deb4a5db7b582522866bad92023-08-25T05:13:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.11784041178404The causal relationship between genetically determined telomere length and meningiomas riskWeijie Yu0Weijie Yu1Yunyun Mei2Zhenwei Lu3Zhenwei Lu4Liwei Zhou5Fang Jia6Fang Jia7Sifang Chen8Sifang Chen9Zhanxiang Wang10Zhanxiang Wang11The School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaDepartment of Neurosurgery, Fudan University Shanghai Cancer Center (Xiamen Hospital), Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Brain Center, Xiamen, ChinaBackgroundStudies have shown that longer leukocyte telomere length (LTL) is significantly associated with increased risk of meningioma. However, there is limited evidence concerning the causal association of LTL with benign and malignant meningiomas or with the location of benign tumors.MethodsWe used three LTL datasets from different sources, designated by name and sample size as LTL-78592, LTL-9190, and LTL-472174. The linkage disequilibrium score (LDSC) was used to explore the association between LTL and meningioma. We utilized two-sample bidirectional Mendelian randomization (TSMR) to evaluate whether LTL is causally related to meningioma risk. We adjusted for confounders by conducting multivariable Mendelian randomization (MVMR).ResultsIn the LTL-78592, longer LTL was significantly associated with increased risk of malignant [odds ratio (OR) = 5.14, p = 1.04 × 10−5], benign (OR = 4.81, p < 0.05), benign cerebral (OR = 5.36, p < 0.05), and benign unspecified meningioma (OR = 8.26, p < 0.05). The same results were obtained for the LTL-9190. In the LTL-472174, longer LTL was significantly associated with increased risk of malignant (OR = 4.94, p < 0.05), benign (OR = 3.14, p < 0.05), and benign cerebral meningioma (OR = 3.59, p < 0.05). Similar results were obtained in the MVMR. In contrast, only benign cerebral meningioma displayed a possible association with longer LTL (OR = 1.01, p < 0.05). No heterogeneity or horizontal pleiotropy was detected.ConclusionIn brief, genetically predicted longer LTL may increase the risk of benign, malignant, and benign cerebral meningiomas, regardless of the LTL measure, in European populations.https://www.frontiersin.org/articles/10.3389/fneur.2023.1178404/fullMendelian randomizationmeningiomastelomere lengthcausalityrisk |
| spellingShingle | Weijie Yu Weijie Yu Yunyun Mei Zhenwei Lu Zhenwei Lu Liwei Zhou Fang Jia Fang Jia Sifang Chen Sifang Chen Zhanxiang Wang Zhanxiang Wang The causal relationship between genetically determined telomere length and meningiomas risk Frontiers in Neurology Mendelian randomization meningiomas telomere length causality risk |
| title | The causal relationship between genetically determined telomere length and meningiomas risk |
| title_full | The causal relationship between genetically determined telomere length and meningiomas risk |
| title_fullStr | The causal relationship between genetically determined telomere length and meningiomas risk |
| title_full_unstemmed | The causal relationship between genetically determined telomere length and meningiomas risk |
| title_short | The causal relationship between genetically determined telomere length and meningiomas risk |
| title_sort | causal relationship between genetically determined telomere length and meningiomas risk |
| topic | Mendelian randomization meningiomas telomere length causality risk |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178404/full |
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