Combination of NOS- and PDK-Inhibitory Activity: Possible Way to Enhance Antitumor Effects

Combination of NOS- and PDK-Inhibitory Activity: Possible Way to Enhance Antitumor Effects

We have previously demonstrated a high antitumor potential of NOS inhibitor T1023 (1-isobutanoyl-2-isopropylisothiourea hydrobromide): antitumor antiangiogenic activity in several animal tumor models and its ability to synergistically enhance the antitumor effects of bevacizumab, cyclophosphamide an...

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Bibliographic Details
Main Authors: Marina Filimonova, Anna Shitova, Olga Soldatova, Ljudmila Shevchenko, Alina Saburova, Tatjana Podosinnikova, Valentina Surinova, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Alexander Filimonov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
NOS-inhibitor
PDK-inhibitor
antitumor effect
hypoxic resistance
Erlich carcinoma
Online Access:https://www.mdpi.com/1422-0067/23/2/730

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