Gene-Specific Targeting of DNA Methylation in the Mammalian Genome

Gene-Specific Targeting of DNA Methylation in the Mammalian Genome

DNA methylation is the most widely-studied epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases. For example, aberrant DNA methylation in promoter regions of tumor-suppressor gen...

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Bibliographic Details
Main Authors: Arthur Urbano, Jim Smith, Robert J. Weeks, Aniruddha Chatterjee
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
dna methylation
cancer
crispr
editing
epigenetics
Online Access:https://www.mdpi.com/2072-6694/11/10/1515

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