Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evalua...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-11-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338211039676 |
| _version_ | 1824014826857299968 |
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| author | Jie Zhang PhD Di Wu PhD Ziran Zhang PhD Jieran Long PhD Guangming Tian PhD Yang Wang PhD Xiangjuan Ma PhD Xiaoling Chen PhD Jindi Han PhD Weiheng Hu PhD Ling Dai PhD Jun Nie PhD Jian Fang PhD |
| author_facet | Jie Zhang PhD Di Wu PhD Ziran Zhang PhD Jieran Long PhD Guangming Tian PhD Yang Wang PhD Xiangjuan Ma PhD Xiaoling Chen PhD Jindi Han PhD Weiheng Hu PhD Ling Dai PhD Jun Nie PhD Jian Fang PhD |
| author_sort | Jie Zhang PhD |
| collection | DOAJ |
| description | Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evaluate the response and complications of patients with advanced NSCLC treated with pembrolizumab or bevacizumab plus chemotherapy. Methods: This study was a retrospective cohort study of patients with advanced nonsquamous NSCLC who received cisplatin with pemetrexed combined with pembrolizumab (A group) or bevacizumab (B group) from 07/02/2018 to 07/03/2021 at Peking University Cancer Hospital. Progression-free survival (PFS) was the primary outcome. The secondary outcomes included overall survival (OS), objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and adverse events (AEs). Results: This study included 66 patients, 34 in A group and 32 in B group. There were no differences in median PFS (7.6 vs 9.9 months, P = .601). There were no differences in median OS (23.1 vs 24.2 months, P = .782). There were no differences in ORR (57.6 % vs 41.9 % , P = .211) and DCR (93.9 % vs 100.0 % , P = .164) between 2 groups. The occurrence of AEs was similar. No new safety signals were observed. Grade 3 to 4 treatment-related AEs occurred in 17 (50.0 % ) patients of A group and in 12 (37.5 % ) of B group ( P > .05). Conclusion: The addition of pembrolizumab or bevacizumab to pemetrexed plus cisplatin was well tolerated and resulted in a clinically meaningful treatment benefit in advanced nonsquamous NSCLC. When pembrolizumab is not suitable, bevacizumab plus chemotherapy may be an option. |
| first_indexed | 2024-12-18T22:19:48Z |
| format | Article |
| id | doaj.art-31934071c47149bf87053edf3807d5a3 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-12-18T22:19:48Z |
| publishDate | 2021-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-31934071c47149bf87053edf3807d5a32022-12-21T20:49:42ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-11-012010.1177/15330338211039676Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort StudyJie Zhang PhDDi Wu PhDZiran Zhang PhDJieran Long PhDGuangming Tian PhDYang Wang PhDXiangjuan Ma PhDXiaoling Chen PhDJindi Han PhDWeiheng Hu PhDLing Dai PhDJun Nie PhDJian Fang PhDObjective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evaluate the response and complications of patients with advanced NSCLC treated with pembrolizumab or bevacizumab plus chemotherapy. Methods: This study was a retrospective cohort study of patients with advanced nonsquamous NSCLC who received cisplatin with pemetrexed combined with pembrolizumab (A group) or bevacizumab (B group) from 07/02/2018 to 07/03/2021 at Peking University Cancer Hospital. Progression-free survival (PFS) was the primary outcome. The secondary outcomes included overall survival (OS), objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and adverse events (AEs). Results: This study included 66 patients, 34 in A group and 32 in B group. There were no differences in median PFS (7.6 vs 9.9 months, P = .601). There were no differences in median OS (23.1 vs 24.2 months, P = .782). There were no differences in ORR (57.6 % vs 41.9 % , P = .211) and DCR (93.9 % vs 100.0 % , P = .164) between 2 groups. The occurrence of AEs was similar. No new safety signals were observed. Grade 3 to 4 treatment-related AEs occurred in 17 (50.0 % ) patients of A group and in 12 (37.5 % ) of B group ( P > .05). Conclusion: The addition of pembrolizumab or bevacizumab to pemetrexed plus cisplatin was well tolerated and resulted in a clinically meaningful treatment benefit in advanced nonsquamous NSCLC. When pembrolizumab is not suitable, bevacizumab plus chemotherapy may be an option.https://doi.org/10.1177/15330338211039676 |
| spellingShingle | Jie Zhang PhD Di Wu PhD Ziran Zhang PhD Jieran Long PhD Guangming Tian PhD Yang Wang PhD Xiangjuan Ma PhD Xiaoling Chen PhD Jindi Han PhD Weiheng Hu PhD Ling Dai PhD Jun Nie PhD Jian Fang PhD Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study Technology in Cancer Research & Treatment |
| title | Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study |
| title_full | Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study |
| title_fullStr | Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study |
| title_full_unstemmed | Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study |
| title_short | Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study |
| title_sort | pembrolizumab or bevacizumab plus chemotherapy as first line treatment of advanced nonsquamous nonsmall cell lung cancer a retrospective cohort study |
| url | https://doi.org/10.1177/15330338211039676 |
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