Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study
Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the potential effect of 3 months’ supplementation with Quercetin Phytosome<sup>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/1/66 |
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| author | Mariangela Rondanelli Simone Perna Clara Gasparri Giovanna Petrangolini Pietro Allegrini Alessandro Cavioni Milena Anna Faliva Francesca Mansueto Zaira Patelli Gabriella Peroni Alice Tartara Antonella Riva |
| author_facet | Mariangela Rondanelli Simone Perna Clara Gasparri Giovanna Petrangolini Pietro Allegrini Alessandro Cavioni Milena Anna Faliva Francesca Mansueto Zaira Patelli Gabriella Peroni Alice Tartara Antonella Riva |
| author_sort | Mariangela Rondanelli |
| collection | DOAJ |
| description | Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the potential effect of 3 months’ supplementation with Quercetin Phytosome<sup>®</sup> (250 mg twice a day) as prevention against symptomatic COVID-19. In total, 120 subjects were enrolled (males, 63; females, 57; age 49 ± 12), with 60 in the supplementation group and 60 in the placebo group. No significant differences were detected between groups in terms of gender, smoking, and chronic disease. Subjects underwent rapid COVID-19 diagnostic tests every 3 weeks. During our study, 5 subjects had COVID-19, 1 out of 60 subjects in the quercetin group and 4 out of 60 in the control group. Complete clinical remission was recorded at 7 and 15 days in the quercetin and placebo groups, respectively. Analysis showed that, at 5 months, the COVID free survival function (risk of infection) was 99.8% in subjects under quercetin supplementation and 96.5% in control group. As shown by the value of EXP(B), those who had taken the supplement had a protection factor of 14% more to not contract the COVID-19 infection than that of those who had taken a placebo. Obtained results are encouraging, but further studies are required to add quercetin as regular prophylaxis. |
| first_indexed | 2024-03-10T01:07:11Z |
| format | Article |
| id | doaj.art-319342b52f114a1194fd1b460c49e5d3 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T01:07:11Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-319342b52f114a1194fd1b460c49e5d32023-11-23T14:24:25ZengMDPI AGLife2075-17292022-01-011216610.3390/life12010066Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot StudyMariangela Rondanelli0Simone Perna1Clara Gasparri2Giovanna Petrangolini3Pietro Allegrini4Alessandro Cavioni5Milena Anna Faliva6Francesca Mansueto7Zaira Patelli8Gabriella Peroni9Alice Tartara10Antonella Riva11IRCCS Mondino Foundation, 27100 Pavia, ItalyDepartment of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq 32038, BahrainEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyResearch and Development Unit, Indena SpA, 20139 Milan, ItalyResearch and Development Unit, Indena SpA, 20139 Milan, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, ItalyResearch and Development Unit, Indena SpA, 20139 Milan, ItalyQuercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for the potential counterbalance of a COVID-19 infection. Given this background, the aim of the study was to evaluate the potential effect of 3 months’ supplementation with Quercetin Phytosome<sup>®</sup> (250 mg twice a day) as prevention against symptomatic COVID-19. In total, 120 subjects were enrolled (males, 63; females, 57; age 49 ± 12), with 60 in the supplementation group and 60 in the placebo group. No significant differences were detected between groups in terms of gender, smoking, and chronic disease. Subjects underwent rapid COVID-19 diagnostic tests every 3 weeks. During our study, 5 subjects had COVID-19, 1 out of 60 subjects in the quercetin group and 4 out of 60 in the control group. Complete clinical remission was recorded at 7 and 15 days in the quercetin and placebo groups, respectively. Analysis showed that, at 5 months, the COVID free survival function (risk of infection) was 99.8% in subjects under quercetin supplementation and 96.5% in control group. As shown by the value of EXP(B), those who had taken the supplement had a protection factor of 14% more to not contract the COVID-19 infection than that of those who had taken a placebo. Obtained results are encouraging, but further studies are required to add quercetin as regular prophylaxis.https://www.mdpi.com/2075-1729/12/1/66quercetinCOVID-19SARS-CoV-2prevention |
| spellingShingle | Mariangela Rondanelli Simone Perna Clara Gasparri Giovanna Petrangolini Pietro Allegrini Alessandro Cavioni Milena Anna Faliva Francesca Mansueto Zaira Patelli Gabriella Peroni Alice Tartara Antonella Riva Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study Life quercetin COVID-19 SARS-CoV-2 prevention |
| title | Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study |
| title_full | Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study |
| title_fullStr | Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study |
| title_full_unstemmed | Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study |
| title_short | Promising Effects of 3-Month Period of Quercetin Phytosome<sup>®</sup> Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study |
| title_sort | promising effects of 3 month period of quercetin phytosome sup r sup supplementation in the prevention of symptomatic covid 19 disease in healthcare workers a pilot study |
| topic | quercetin COVID-19 SARS-CoV-2 prevention |
| url | https://www.mdpi.com/2075-1729/12/1/66 |
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