Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis
Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way. In this review, we focused on the impact of hypoxia in the physiopathology of idiopathic pulmo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/19/2938 |
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| author | Ana Karen Torres-Soria Yair Romero Yalbi I. Balderas-Martínez Rafael Velázquez-Cruz Luz Maria Torres-Espíndola Angel Camarena Edgar Flores-Soto Héctor Solís-Chagoyán Víctor Ruiz Ángeles Carlos-Reyes Citlaltepetl Salinas-Lara Erika Rubí Luis-García Jaime Chávez Manuel Castillejos-López Arnoldo Aquino-Gálvez |
| author_facet | Ana Karen Torres-Soria Yair Romero Yalbi I. Balderas-Martínez Rafael Velázquez-Cruz Luz Maria Torres-Espíndola Angel Camarena Edgar Flores-Soto Héctor Solís-Chagoyán Víctor Ruiz Ángeles Carlos-Reyes Citlaltepetl Salinas-Lara Erika Rubí Luis-García Jaime Chávez Manuel Castillejos-López Arnoldo Aquino-Gálvez |
| author_sort | Ana Karen Torres-Soria |
| collection | DOAJ |
| description | Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way. In this review, we focused on the impact of hypoxia in the physiopathology of idiopathic pulmonary fibrosis (IPF) related to lung development, regeneration, and repair. There is robust evidence that the responses of HIF-1α and -2α differ; HIF-1α participates mainly in the acute phase of the response to hypoxia, and HIF-2α in the chronic phase. The analysis of their structure and of different studies showed a high specificity according to the tissue and the process involved. We propose that hypoxia-inducible transcription factor 2a (HIF-2α) is part of the persistent aberrant regeneration associated with developing IPF. |
| first_indexed | 2024-03-09T21:54:34Z |
| format | Article |
| id | doaj.art-3193622223214ebbae3bff96ff1a4595 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:54:34Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3193622223214ebbae3bff96ff1a45952023-11-23T19:59:50ZengMDPI AGCells2073-44092022-09-011119293810.3390/cells11192938Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary FibrosisAna Karen Torres-Soria0Yair Romero1Yalbi I. Balderas-Martínez2Rafael Velázquez-Cruz3Luz Maria Torres-Espíndola4Angel Camarena5Edgar Flores-Soto6Héctor Solís-Chagoyán7Víctor Ruiz8Ángeles Carlos-Reyes9Citlaltepetl Salinas-Lara10Erika Rubí Luis-García11Jaime Chávez12Manuel Castillejos-López13Arnoldo Aquino-Gálvez14Red MEDICI, Carrera de Médico Cirujano, Facultad de Estudios Superiores de Iztacala Universidad Nacional Autónoma de México, Mexico City 54090, MexicoFacultad de Ciencias, Universidad Nacional Autónoma México, Mexico City 04510, MexicoLaboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoLaboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoLaboratorio de Farmacología, Instituto Nacional de Pediatría, Mexico City 04530, MexicoLaboratorio de HLA, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 04530, MexicoDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoSubdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, MexicoDepartamento de Fibrosis Pulmonar, Laboratorio de Biología Molecular, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoLaboratorio de Onco-Inmunobiología, Departamento de Enfermedades Crónico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoRed MEDICI, Carrera de Médico Cirujano, Facultad de Estudios Superiores de Iztacala Universidad Nacional Autónoma de México, Mexico City 54090, MexicoDepartamento de Fibrosis Pulmonar, Laboratorio de Biología Celular, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoDepartamento de Hiperreactividad Bronquial, Instituto Nacional de Enfermedades, Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoDepartamento de Epidemiología y Estadística, Instituto Nacional de Enfermedades, Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoDepartamento de Fibrosis Pulmonar, Laboratorio de Biología Molecular, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoHypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way. In this review, we focused on the impact of hypoxia in the physiopathology of idiopathic pulmonary fibrosis (IPF) related to lung development, regeneration, and repair. There is robust evidence that the responses of HIF-1α and -2α differ; HIF-1α participates mainly in the acute phase of the response to hypoxia, and HIF-2α in the chronic phase. The analysis of their structure and of different studies showed a high specificity according to the tissue and the process involved. We propose that hypoxia-inducible transcription factor 2a (HIF-2α) is part of the persistent aberrant regeneration associated with developing IPF.https://www.mdpi.com/2073-4409/11/19/2938lung regenerationIPFHIFshypoxia |
| spellingShingle | Ana Karen Torres-Soria Yair Romero Yalbi I. Balderas-Martínez Rafael Velázquez-Cruz Luz Maria Torres-Espíndola Angel Camarena Edgar Flores-Soto Héctor Solís-Chagoyán Víctor Ruiz Ángeles Carlos-Reyes Citlaltepetl Salinas-Lara Erika Rubí Luis-García Jaime Chávez Manuel Castillejos-López Arnoldo Aquino-Gálvez Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis Cells lung regeneration IPF HIFs hypoxia |
| title | Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis |
| title_full | Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis |
| title_fullStr | Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis |
| title_short | Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis |
| title_sort | functional repercussions of hypoxia inducible factor 2α in idiopathic pulmonary fibrosis |
| topic | lung regeneration IPF HIFs hypoxia |
| url | https://www.mdpi.com/2073-4409/11/19/2938 |
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