Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts
<i>Vitis vinifera</i> (<i>V. vinifera</i>) is a herbaceous plant, cultivated worldwide and known for its biological benefits. The aim of this study is the investigation of the chemical composition as well as the determination of the biological potential of different grape ste...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/10/3109 |
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| author | Talel Ben Khadher Samir Aydi Mohamed Mars Jalloul Bouajila |
| author_facet | Talel Ben Khadher Samir Aydi Mohamed Mars Jalloul Bouajila |
| author_sort | Talel Ben Khadher |
| collection | DOAJ |
| description | <i>Vitis vinifera</i> (<i>V. vinifera</i>) is a herbaceous plant, cultivated worldwide and known for its biological benefits. The aim of this study is the investigation of the chemical composition as well as the determination of the biological potential of different grape stem extracts obtained by maceration and accelerated solvent extraction (ASE). The HPLC analysis of the tested extracts led to the identification of 28 compounds of which 17 were identified for the first time in grape plants, in addition to seven revealed in the stem part for the first time. Twenty-nine volatile molecules have been detected by GC-MS in the grape stem part; among them seven were identified for the first time in the grape plant. For the biological analysis, the ethyl acetate extract (EtOAc) obtained by maceration showed a significant potential regarding antioxidant activity (IC<sub>50</sub> = 42.5 µg/mL), anti-Alzheimer (IC<sub>50</sub> = 14.1 µg/mL), antidiabetic (IC<sub>50</sub> = 13.4 µg/mL), cytotoxic with HCT-116 (IC<sub>50</sub> = 12.5 µg/mL), and anti-inflammatory (IC<sub>50</sub> = 26.6 µg/mL) activities, as well as showing the highest polyphenol content (207.9 mg GAE/g DW). |
| first_indexed | 2024-03-10T03:19:55Z |
| format | Article |
| id | doaj.art-31962ad24bd44adabc7251d925481d4f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:19:55Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-31962ad24bd44adabc7251d925481d4f2023-11-23T12:21:11ZengMDPI AGMolecules1420-30492022-05-012710310910.3390/molecules27103109Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem ExtractsTalel Ben Khadher0Samir Aydi1Mohamed Mars2Jalloul Bouajila3Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INP, UPS, F-31062 Toulouse, FranceLaboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, TunisiaLaboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, TunisiaLaboratoire de Génie Chimique, Université de Toulouse, CNRS, INP, UPS, F-31062 Toulouse, France<i>Vitis vinifera</i> (<i>V. vinifera</i>) is a herbaceous plant, cultivated worldwide and known for its biological benefits. The aim of this study is the investigation of the chemical composition as well as the determination of the biological potential of different grape stem extracts obtained by maceration and accelerated solvent extraction (ASE). The HPLC analysis of the tested extracts led to the identification of 28 compounds of which 17 were identified for the first time in grape plants, in addition to seven revealed in the stem part for the first time. Twenty-nine volatile molecules have been detected by GC-MS in the grape stem part; among them seven were identified for the first time in the grape plant. For the biological analysis, the ethyl acetate extract (EtOAc) obtained by maceration showed a significant potential regarding antioxidant activity (IC<sub>50</sub> = 42.5 µg/mL), anti-Alzheimer (IC<sub>50</sub> = 14.1 µg/mL), antidiabetic (IC<sub>50</sub> = 13.4 µg/mL), cytotoxic with HCT-116 (IC<sub>50</sub> = 12.5 µg/mL), and anti-inflammatory (IC<sub>50</sub> = 26.6 µg/mL) activities, as well as showing the highest polyphenol content (207.9 mg GAE/g DW).https://www.mdpi.com/1420-3049/27/10/3109<i>Vitis vinifera</i> stem extractschemical compositionbiological activitiesHPLC-DADGC-MS |
| spellingShingle | Talel Ben Khadher Samir Aydi Mohamed Mars Jalloul Bouajila Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts Molecules <i>Vitis vinifera</i> stem extracts chemical composition biological activities HPLC-DAD GC-MS |
| title | Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts |
| title_full | Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts |
| title_fullStr | Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts |
| title_full_unstemmed | Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts |
| title_short | Study on the Chemical Composition and the Biological Activities of <i>Vitis vinifera</i> Stem Extracts |
| title_sort | study on the chemical composition and the biological activities of i vitis vinifera i stem extracts |
| topic | <i>Vitis vinifera</i> stem extracts chemical composition biological activities HPLC-DAD GC-MS |
| url | https://www.mdpi.com/1420-3049/27/10/3109 |
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