Age-Related Normogram for Ovarian Antral Follicle Count in Women with Polycystic Ovary Syndrome and Comparison with Age Matched Controls Using Magnetic Resonance Imaging
Introduction: Antral Follicle count (AFC) is a reliable marker for ovarian reserve. Previous studies have used transvaginal ultrasound for estimation of AFC, however we used magnetic resonance imaging (MRI) for estimation of AFC and for creating an age-related normogram in patients with polycyst...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7136/17334_CE[Ra]_F(Sh)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Antral Follicle count (AFC) is a reliable marker
for ovarian reserve. Previous studies have used transvaginal
ultrasound for estimation of AFC, however we used magnetic
resonance imaging (MRI) for estimation of AFC and for creating
an age-related normogram in patients with polycystic ovary
syndrome (PCOS) and compared it with normal patients.
Aim: The aim of this study is to create an age related normogram
for AFC in women with PCOS and to compare that with women
without polycystic ovarian syndrome using MRI.
Materials and Methods: A total of 1500 women were examined,
out of which 400 fitted the criteria for PCOS. They all underwent
MRI study and similar age matched women without PCOS also
underwent MRI examination. Normogram for AFC were obtained
using LMS software and a percentile chart was obtained.
Results: Normogram for AFC in PCOS women showed decline
in number of AFC as the age progresses and the decline was
linear. The normogram for AFC was compared with equal number
of patients without PCOS and they also showed decline in AFC
as the age progresses, however the decline was exponential
and faster.
Conclusion: Age related normogram for AFC is widely used
and considered as best clinical predictor for ovarian response
in assisted reproductive technology. Knowledge of ovarian
reserve is important in PCOS and non-PCOS females as PCOS
patients are at risk for ovarian hyperstimulation syndrome
during gonadotrophin theraphy. MRI is an equally effective and
in some times better alternative to transvaginal ultrasound as it
has got its own advantages. |
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| ISSN: | 2249-782X 0973-709X |