Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution
In this study, a flexible optimization approach is introduced to design an optimal biocompatible solvent for an extractive fermentation process with cell-recycling. The optimal process/solvent design problem is formulated as a mixed-integer nonlinear programming model in which performance requiremen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Academic Publishing House
2008-04-01
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| Series: | Bioautomation |
| Subjects: | |
| Online Access: | http://www.clbme.bas.bg/bioautomation/2008/vol_9.1/files/9_2.2.pdf |
| _version_ | 1818542909674225664 |
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| author | Hou-Chieh Cheng Feng-Sheng Wang |
| author_facet | Hou-Chieh Cheng Feng-Sheng Wang |
| author_sort | Hou-Chieh Cheng |
| collection | DOAJ |
| description | In this study, a flexible optimization approach is introduced to design an optimal biocompatible solvent for an extractive fermentation process with cell-recycling. The optimal process/solvent design problem is formulated as a mixed-integer nonlinear programming model in which performance requirements of the compounds are reflected in the objectives and the constraints. A flexible or fuzzy optimization approach is applied to soften the rigid requirement for maximization of the production rate, extraction efficiency and to consider the solvent utilization rate as the softened inequality constraint to the process/solvent design problem. Such a trade-off problem is then converted to the goal attainment problem, which is described as the constrained mixed-integer nonlinear programming (MINLP) problem. Mixed-integer hybrid differential evolution with multiplier updating method is introduced to solve the constrained MINLP problem. The adaptive penalty updating scheme is more efficient to achieve a global design. |
| first_indexed | 2024-12-11T22:28:21Z |
| format | Article |
| id | doaj.art-31968fae542346cd98e6b2477e7b4aac |
| institution | Directory Open Access Journal |
| issn | 1313-261X 1312-451X |
| language | English |
| last_indexed | 2024-12-11T22:28:21Z |
| publishDate | 2008-04-01 |
| publisher | Academic Publishing House |
| record_format | Article |
| series | Bioautomation |
| spelling | doaj.art-31968fae542346cd98e6b2477e7b4aac2022-12-22T00:48:13ZengAcademic Publishing HouseBioautomation1313-261X1312-451X2008-04-01911530Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential EvolutionHou-Chieh ChengFeng-Sheng WangIn this study, a flexible optimization approach is introduced to design an optimal biocompatible solvent for an extractive fermentation process with cell-recycling. The optimal process/solvent design problem is formulated as a mixed-integer nonlinear programming model in which performance requirements of the compounds are reflected in the objectives and the constraints. A flexible or fuzzy optimization approach is applied to soften the rigid requirement for maximization of the production rate, extraction efficiency and to consider the solvent utilization rate as the softened inequality constraint to the process/solvent design problem. Such a trade-off problem is then converted to the goal attainment problem, which is described as the constrained mixed-integer nonlinear programming (MINLP) problem. Mixed-integer hybrid differential evolution with multiplier updating method is introduced to solve the constrained MINLP problem. The adaptive penalty updating scheme is more efficient to achieve a global design.http://www.clbme.bas.bg/bioautomation/2008/vol_9.1/files/9_2.2.pdf Biocompatible solventFlexible optimization approachExtractive fermentation |
| spellingShingle | Hou-Chieh Cheng Feng-Sheng Wang Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution Bioautomation Biocompatible solvent Flexible optimization approach Extractive fermentation |
| title | Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution |
| title_full | Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution |
| title_fullStr | Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution |
| title_full_unstemmed | Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution |
| title_short | Optimal Biocompatible Solvent Design by Mixed-integer Hybrid Differential Evolution |
| title_sort | optimal biocompatible solvent design by mixed integer hybrid differential evolution |
| topic | Biocompatible solvent Flexible optimization approach Extractive fermentation |
| url | http://www.clbme.bas.bg/bioautomation/2008/vol_9.1/files/9_2.2.pdf |
| work_keys_str_mv | AT houchiehcheng optimalbiocompatiblesolventdesignbymixedintegerhybriddifferentialevolution AT fengshengwang optimalbiocompatiblesolventdesignbymixedintegerhybriddifferentialevolution |