Modulation in the microRNA repertoire is responsible for the stage-specific effects of Akt suppression on murine neuroendocrine prostate cancer

Modulation in the microRNA repertoire is responsible for the stage-specific effects of Akt suppression on murine neuroendocrine prostate cancer

Recent studies indicate a stage-specific, differential role for the oncogene Akt on various cancers. In prostate cancer (PCa), suppression of Akt activity in the advanced stages promoted transforming growth factor-β (TGFβ) pathway-mediated epithelial-to-mesenchymal transition (EMT) and metastasis to...

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Bibliographic Details
Main Authors: Abdulrahman Alwhaibi, Fei Gao, Sandeep Artham, Bernard M. Hsia, Ashis Mondal, Ravindra Kolhe, Payaningal R. Somanath
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Heliyon
Subjects:
Biochemistry
Bioinformatics
Cancer research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018344219

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