New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i>
New diterpenes, namely, trichodermanins F−H, with a fused 6-5-6-6 ring system were isolated from the fungus <i>Trichoderma harzianum</i> OUPS-111D-4 separated from a marine sponge <i>Halichondria okadai</i>. These chemical structures were elucidated by 1D and 2D NMR...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/8/480 |
| _version_ | 1798041520308224000 |
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| author | Takeshi Yamada Ayano Fujii Takashi Kikuchi |
| author_facet | Takeshi Yamada Ayano Fujii Takashi Kikuchi |
| author_sort | Takeshi Yamada |
| collection | DOAJ |
| description | New diterpenes, namely, trichodermanins F−H, with a fused 6-5-6-6 ring system were isolated from the fungus <i>Trichoderma harzianum</i> OUPS-111D-4 separated from a marine sponge <i>Halichondria okadai</i>. These chemical structures were elucidated by 1D and 2D NMR as well as high-resolution fast atom bombardment mass spectrometry (HRFABMS) spectral analyses. We established their absolute stereostructures by application of the modified Mosher’s method or circular dichroism (CD) spectroscopy. In addition, their cytotoxicities were assessed using several cancer cell lines, with <b>1</b> and <b>2</b> exhibiting modest activities. |
| first_indexed | 2024-04-11T22:22:39Z |
| format | Article |
| id | doaj.art-319afce94ad042b99306f68bcf2760cf |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:22:39Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-319afce94ad042b99306f68bcf2760cf2022-12-22T03:59:59ZengMDPI AGMarine Drugs1660-33972019-08-0117848010.3390/md17080480md17080480New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i>Takeshi Yamada0Ayano Fujii1Takashi Kikuchi2Department of Medicinal Molecular Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Medicinal Molecular Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Medicinal Molecular Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, JapanNew diterpenes, namely, trichodermanins F−H, with a fused 6-5-6-6 ring system were isolated from the fungus <i>Trichoderma harzianum</i> OUPS-111D-4 separated from a marine sponge <i>Halichondria okadai</i>. These chemical structures were elucidated by 1D and 2D NMR as well as high-resolution fast atom bombardment mass spectrometry (HRFABMS) spectral analyses. We established their absolute stereostructures by application of the modified Mosher’s method or circular dichroism (CD) spectroscopy. In addition, their cytotoxicities were assessed using several cancer cell lines, with <b>1</b> and <b>2</b> exhibiting modest activities.https://www.mdpi.com/1660-3397/17/8/480diterpenestrichodermanins<i>Trichoderma harzianum</i><i>Halichondria okadai</i>fused 6-5-6-6 ring systemcytotoxicity |
| spellingShingle | Takeshi Yamada Ayano Fujii Takashi Kikuchi New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> Marine Drugs diterpenes trichodermanins <i>Trichoderma harzianum</i> <i>Halichondria okadai</i> fused 6-5-6-6 ring system cytotoxicity |
| title | New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> |
| title_full | New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> |
| title_fullStr | New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> |
| title_full_unstemmed | New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> |
| title_short | New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus <i>Trichoderma harzianum</i> |
| title_sort | new diterpenes with a fused 6 5 6 6 ring system isolated from the marine sponge derived fungus i trichoderma harzianum i |
| topic | diterpenes trichodermanins <i>Trichoderma harzianum</i> <i>Halichondria okadai</i> fused 6-5-6-6 ring system cytotoxicity |
| url | https://www.mdpi.com/1660-3397/17/8/480 |
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