Deletion of the Stress Response Gene <i>DDR48</i> from <i>Histoplasma capsulatum</i> Increases Sensitivity to Oxidative Stress, Increases Susceptibility to Antifungals, and Decreases Fitness in Macrophages

Deletion of the Stress Response Gene <i>DDR48</i> from <i>Histoplasma capsulatum</i> Increases Sensitivity to Oxidative Stress, Increases Susceptibility to Antifungals, and Decreases Fitness in Macrophages

The stress response gene <i>DDR48</i> has been characterized in <i>Saccharomyces cerevisiae</i> and <i>Candida albicans</i> to be involved in combating various cellular stressors, from oxidative agents to antifungal compounds. Surprisingly, the biological function...

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Bibliographic Details
Main Authors: Logan T. Blancett, Kauri A. Runge, Gabriella M. Reyes, Lauren A. Kennedy, Sydney C. Jackson, Sarah E. Scheuermann, Mallory B. Harmon, Jamease C. Williams, Glenmore Shearer
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Journal of Fungi
Subjects:
<i>Histoplasma</i>
<i>DDR48</i>
paraquat
hydrogen peroxide
amphotericin-B
ketoconazole
Online Access:https://www.mdpi.com/2309-608X/7/11/981

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