MIF promotes cell invasion by the LRP1-uPAR interaction in pancreatic cancer cells

MIF promotes cell invasion by the LRP1-uPAR interaction in pancreatic cancer cells

IntroductionPancreatic ductal adenocarcinoma (PDAC) is characterized by high aggressiveness and a hypoxic tumour microenvironment. Macrophage migration inhibitory factor (MIF) is a hypoxia-related pleiotropic cytokine that plays important roles in cancer. However, its role in PDAC progression has no...

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Bibliographic Details
Main Authors: Huizhi Sun, Runfen Cheng, Danfang Zhang, Yuhong Guo, Fan Li, Yanlei Li, Yue Li, Xiaoyu Bai, Jing Mo, Chongbiao Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
MIF
uPAR
LRP1
hypoxia
spatial transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1028070/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1028070/full

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