Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan
Background: Bronchial asthma is a chronic inflammatory disease that has a severe impact on health worldwide. Methods: A survey of 10,771 patients with bronchial asthma in the Tama region, Tokyo was conducted for 5 years to examine treatment and quality of life (QOL). Subjects were patients aged ≥16...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015305554 |
| _version_ | 1818476935779450880 |
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| author | Nobuharu Ohshima Hirotoshi Matsui Yoshinori Matsui Masahiro Kawashima Masahiro Shimada Naoko Higaki Shunsuke Shoji Hiroo Wada Akira Fujita Hidehiro Watanabe Norio Yamaguchi Rokuro Matsuoka Kazuhiko Oki Hisaho Takahashi Michiaki Suzuki Hiroomi Yamazaki Masafumi Yoshizawa Hajime Goto |
| author_facet | Nobuharu Ohshima Hirotoshi Matsui Yoshinori Matsui Masahiro Kawashima Masahiro Shimada Naoko Higaki Shunsuke Shoji Hiroo Wada Akira Fujita Hidehiro Watanabe Norio Yamaguchi Rokuro Matsuoka Kazuhiko Oki Hisaho Takahashi Michiaki Suzuki Hiroomi Yamazaki Masafumi Yoshizawa Hajime Goto |
| author_sort | Nobuharu Ohshima |
| collection | DOAJ |
| description | Background: Bronchial asthma is a chronic inflammatory disease that has a severe impact on health worldwide.
Methods: A survey of 10,771 patients with bronchial asthma in the Tama region, Tokyo was conducted for 5 years to examine treatment and quality of life (QOL). Subjects were patients aged ≥16 years and their physicians who replied to a questionnaire sent in November from 2002 to 2006. Symptoms of bronchial asthma, visits to an emergency room, use of drugs, and severity of asthma were investigated.
Results: Asthmatic symptoms improved over the 5 years, with a reduction in the number of emergency room visits. Since inhaled corticosteroids (ICS) were used by >80% of patients in 2002, we suspected that increased use of concomitant leukotriene receptor antagonists (LTRA) and long-acting β2 agonists (LABA) might have contributed to these findings. The effects of these drugs were compared between ICS + LTRA (n = 45) and ICS + LABA (n = 54) groups of patients. There was no significant difference in the ICS dose between these groups. In the ICS + LABA group, 18.5% and 22.2% of patients visited an emergency room before and after initiation of combination therapy, respectively, with no statistically significant difference. In contrast, the rate of emergency room visits in the ICS + LTRA group decreased from 24.4% to 6.6% after addition of LTRA.
Conclusions: These results suggest that the frequency of visits to an emergency room was decreased by complementing the anti-inflammatory effect of ICS with further treatment of inflammation, particularly with LTRA. |
| first_indexed | 2024-12-10T09:31:41Z |
| format | Article |
| id | doaj.art-319d90cce551450b82dbbd6d6033caef |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-10T09:31:41Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-319d90cce551450b82dbbd6d6033caef2022-12-22T01:54:20ZengElsevierAllergology International1323-89302011-01-0160447348110.2332/allergolint.10-OA-0296Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, JapanNobuharu Ohshima0Hirotoshi Matsui1Yoshinori Matsui2Masahiro Kawashima3Masahiro Shimada4Naoko Higaki5Shunsuke Shoji6Hiroo Wada7Akira Fujita8Hidehiro Watanabe9Norio Yamaguchi10Rokuro Matsuoka11Kazuhiko Oki12Hisaho Takahashi13Michiaki Suzuki14Hiroomi Yamazaki15Masafumi Yoshizawa16Hajime Goto17Center for Pulmonary Diseases, Tokyo, Japan.Center for Pulmonary Diseases, Tokyo, Japan.Center for Pulmonary Diseases, Tokyo, Japan.Center for Pulmonary Diseases, Tokyo, Japan.Center for Pulmonary Diseases, Tokyo, Japan.Center for Pulmonary Diseases, Tokyo, Japan.Department of Allergy, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.Department of Pulmonary Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.Division of Respiratory Medicine, Tokai University Hachioji Hospital, Tokyo, Japan.Yamaguchi Chest Clinic, Tokyo, Japan.Matsuoka Clinic, Tokyo, Japan.Oki Clinic, Tokyo, Japan.Takahashi Clinic, Tokyo, Japan.Department of Pulmonary Medicine, Showa General Hospital, Tokyo, Japan.Yamazaki Chest Clinic, Tokyo, Japan.Department of Respiratory Medicine, Musashino Red Cross Hospital, Tokyo, Japan.Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.Background: Bronchial asthma is a chronic inflammatory disease that has a severe impact on health worldwide. Methods: A survey of 10,771 patients with bronchial asthma in the Tama region, Tokyo was conducted for 5 years to examine treatment and quality of life (QOL). Subjects were patients aged ≥16 years and their physicians who replied to a questionnaire sent in November from 2002 to 2006. Symptoms of bronchial asthma, visits to an emergency room, use of drugs, and severity of asthma were investigated. Results: Asthmatic symptoms improved over the 5 years, with a reduction in the number of emergency room visits. Since inhaled corticosteroids (ICS) were used by >80% of patients in 2002, we suspected that increased use of concomitant leukotriene receptor antagonists (LTRA) and long-acting β2 agonists (LABA) might have contributed to these findings. The effects of these drugs were compared between ICS + LTRA (n = 45) and ICS + LABA (n = 54) groups of patients. There was no significant difference in the ICS dose between these groups. In the ICS + LABA group, 18.5% and 22.2% of patients visited an emergency room before and after initiation of combination therapy, respectively, with no statistically significant difference. In contrast, the rate of emergency room visits in the ICS + LTRA group decreased from 24.4% to 6.6% after addition of LTRA. Conclusions: These results suggest that the frequency of visits to an emergency room was decreased by complementing the anti-inflammatory effect of ICS with further treatment of inflammation, particularly with LTRA.http://www.sciencedirect.com/science/article/pii/S1323893015305554bronchial asthmainhaled corticosteroidsleukotriene receptor antagonistsquality of lifesurvey |
| spellingShingle | Nobuharu Ohshima Hirotoshi Matsui Yoshinori Matsui Masahiro Kawashima Masahiro Shimada Naoko Higaki Shunsuke Shoji Hiroo Wada Akira Fujita Hidehiro Watanabe Norio Yamaguchi Rokuro Matsuoka Kazuhiko Oki Hisaho Takahashi Michiaki Suzuki Hiroomi Yamazaki Masafumi Yoshizawa Hajime Goto Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan Allergology International bronchial asthma inhaled corticosteroids leukotriene receptor antagonists quality of life survey |
| title | Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan |
| title_full | Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan |
| title_fullStr | Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan |
| title_full_unstemmed | Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan |
| title_short | Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan |
| title_sort | addition of leukotriene receptor antagonists to inhaled corticosteroids improved qol of patients with bronchial asthma surveyed in suburban tokyo japan |
| topic | bronchial asthma inhaled corticosteroids leukotriene receptor antagonists quality of life survey |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015305554 |
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