| Summary: | Invasive <i>Candida</i> infections have become a global public health problem due to the increase of <i>Candida</i> species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of <i>Candida</i> infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of <i>Candida</i> infections—namely, <i>Candida albicans</i>, <i>Candida glabrata</i>, <i>Candida tropicalis</i>, <i>Candida parapsilosis</i> and <i>Candida krusei</i>. PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five <i>Candida</i> species. On the other hand, PYED-1 exhibited a good anti-biofilm activity, and was able to eradicate the preformed biofilms of all <i>Candida</i> species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of <i>C. albicans</i> and reduced adhesion of <i>C. albicans</i> to abiotic surfaces by up to 30%.
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