High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure

Patients with heart failure (HF) are frequently admitted for episodes of decompensation. Cardiac troponins are easily accessible biomarkers role of which for risk stratification of re-hospitalization among HF patients is less certain. We aimed to evaluate high-sensitive cardiac troponin I (hs-cTnI)...

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Main Authors: Shokoufeh Hajsadeghi, Yaghoub Bagheri, Mohammad Hossein Ghafouri, Scott Reza Jafarian Kerman, Morteza Hassanzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2019-03-01
Series:Acta Medica Iranica
Subjects:
Online Access:http://acta.tums.ac.ir/index.php/acta/article/view/7090
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author Shokoufeh Hajsadeghi
Yaghoub Bagheri
Mohammad Hossein Ghafouri
Scott Reza Jafarian Kerman
Morteza Hassanzadeh
author_facet Shokoufeh Hajsadeghi
Yaghoub Bagheri
Mohammad Hossein Ghafouri
Scott Reza Jafarian Kerman
Morteza Hassanzadeh
author_sort Shokoufeh Hajsadeghi
collection DOAJ
description Patients with heart failure (HF) are frequently admitted for episodes of decompensation. Cardiac troponins are easily accessible biomarkers role of which for risk stratification of re-hospitalization among HF patients is less certain. We aimed to evaluate high-sensitive cardiac troponin I (hs-cTnI) levels among re-hospitalized patients with decompensated heart failure (D-HF). Consecutive subjects admitted with D-HF to 2 hospitals in Tehran, during the year 2014 were recruited. Excluded ones were patients with a suspected acute coronary syndrome or myocarditis/pericarditis, those with cardiopulmonary resuscitation/DC shock delivery, or major complications during or after hospitalization. Along with echocardiography parameters, level of hs-cTnI was checked at the first hour of hospitalization and 3 months after discharge. The patients were then categorized according to having or not having re-hospitalization during 3 months post discharge. A total of 97 patients were finally recruited. Among re-hospitalized patients, Left ventricular (LV) ejection fraction was significantly lower (38±14 % vs. 50 ± 12%; P=0.001), and LV end-systolic dimension was significantly higher (44±9 mm vs. 38±11 mm; P=0.012) compared to the other group. Moreover, levels of hs-cTnI were significantly higher among the re-hospitalized patients, both at initial visit (0.66±0.43 ng/ml vs 0.51±0.14 ng/ml, respectively; P=0.017) and at 3 months (0.59±0.48 ng/ml vs 0.48±0.23 ng/ml, respectively; P=0.030). This prospective study demonstrated that levels of hs-cTnI (both at the base and at follow up) are higher among patients who readmitted during 3 months of hospitalization for D-HF.
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spelling doaj.art-31a21d9a3de04faabba39b1ba5c76fd12022-12-22T00:06:32ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942019-03-011161217090High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart FailureShokoufeh Hajsadeghi0Yaghoub Bagheri1Mohammad Hossein Ghafouri2Scott Reza Jafarian Kerman3Morteza Hassanzadeh4Department of Cardiology, Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Shahid Rajaei Heart Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Medicine, Iran University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.Department of Internal Medicine, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.Patients with heart failure (HF) are frequently admitted for episodes of decompensation. Cardiac troponins are easily accessible biomarkers role of which for risk stratification of re-hospitalization among HF patients is less certain. We aimed to evaluate high-sensitive cardiac troponin I (hs-cTnI) levels among re-hospitalized patients with decompensated heart failure (D-HF). Consecutive subjects admitted with D-HF to 2 hospitals in Tehran, during the year 2014 were recruited. Excluded ones were patients with a suspected acute coronary syndrome or myocarditis/pericarditis, those with cardiopulmonary resuscitation/DC shock delivery, or major complications during or after hospitalization. Along with echocardiography parameters, level of hs-cTnI was checked at the first hour of hospitalization and 3 months after discharge. The patients were then categorized according to having or not having re-hospitalization during 3 months post discharge. A total of 97 patients were finally recruited. Among re-hospitalized patients, Left ventricular (LV) ejection fraction was significantly lower (38±14 % vs. 50 ± 12%; P=0.001), and LV end-systolic dimension was significantly higher (44±9 mm vs. 38±11 mm; P=0.012) compared to the other group. Moreover, levels of hs-cTnI were significantly higher among the re-hospitalized patients, both at initial visit (0.66±0.43 ng/ml vs 0.51±0.14 ng/ml, respectively; P=0.017) and at 3 months (0.59±0.48 ng/ml vs 0.48±0.23 ng/ml, respectively; P=0.030). This prospective study demonstrated that levels of hs-cTnI (both at the base and at follow up) are higher among patients who readmitted during 3 months of hospitalization for D-HF.http://acta.tums.ac.ir/index.php/acta/article/view/7090Decompensated heart failureTroponin IHospitalization
spellingShingle Shokoufeh Hajsadeghi
Yaghoub Bagheri
Mohammad Hossein Ghafouri
Scott Reza Jafarian Kerman
Morteza Hassanzadeh
High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
Acta Medica Iranica
Decompensated heart failure
Troponin I
Hospitalization
title High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
title_full High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
title_fullStr High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
title_full_unstemmed High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
title_short High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure
title_sort high sensitive troponin i and re hospitalization in patients with decompensated congestive heart failure
topic Decompensated heart failure
Troponin I
Hospitalization
url http://acta.tums.ac.ir/index.php/acta/article/view/7090
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