Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies
Introduction: The global protozoan parasite, Toxoplasma gondii, infects many warm-blooded animals and humans by employing different transmission routes. There have been some recent studies on the probable relevance of infectious agents and diabetes. Therefore, we conducted a systematic review and me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867016303348 |
| _version_ | 1818405820598059008 |
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| author | Hamidreza Majidiani Sahar Dalvand Ahmad Daryani Ma de la Luz Galvan-Ramirez Masoud Foroutan-Rad |
| author_facet | Hamidreza Majidiani Sahar Dalvand Ahmad Daryani Ma de la Luz Galvan-Ramirez Masoud Foroutan-Rad |
| author_sort | Hamidreza Majidiani |
| collection | DOAJ |
| description | Introduction: The global protozoan parasite, Toxoplasma gondii, infects many warm-blooded animals and humans by employing different transmission routes. There have been some recent studies on the probable relevance of infectious agents and diabetes. Therefore, we conducted a systematic review and meta-analysis to identify the possible association between chronic toxoplasmosis and diabetes mellitus. Methods: This study was conducted following the general methodology recommended for systematic reviews and meta-analysis. Nine English literature databases (Google scholar, PubMed, Scopus, Web of science, Science Direct, Ovid, ProQuest, IngentaConnect, and Wiley Online Library) were searched, up to January 2016. Random effects model was used to determine odds ratios and their 95% confidence intervals. Results: Our review resulted in a total of seven publications meeting the inclusion criteria. Because of significant heterogeneity, we estimated a common OR by a random effects model at 1.10 (95% CI = 0.13–9.57) with p = 0.929 and 2.39 (95% CI = 1.20–4.75) with p = 0.013 for type 1 and type 2 diabetes mellitus, respectively. Conclusion: Despite the limitations such as low number of studies, this meta-analysis suggests chronic toxoplasmosis as a possible risk factor for type 2 DM. However, based on random effects model no statistically significant association was observed between T. gondii and type 1 DM. It is highly recommended for researchers to carry out more accurate studies aiming to better understand this association. Keywords: Toxoplasma gondii, Diabetes mellitus, Systematic review, Meta-analysis |
| first_indexed | 2024-12-14T09:02:07Z |
| format | Article |
| id | doaj.art-31a230910ec14443bbaf8c7282e4bb28 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-14T09:02:07Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-31a230910ec14443bbaf8c7282e4bb282022-12-21T23:08:48ZengElsevierBrazilian Journal of Infectious Diseases1413-86702016-11-01206605609S1413-86702016000600605Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studiesHamidreza Majidiani0Sahar Dalvand1Ahmad Daryani2Ma de la Luz Galvan-Ramirez3Masoud Foroutan-Rad4Tarbiat Modares University, Faculty of Medical Sciences, Department of Parasitology, Tehran, IranKurdistan University of Medical Sciences, Social Determinants of Health Research Center, Sanandaj, IranMazandaran University of Medical Sciences, Toxoplasmosis Research Center, Sari, IranUniversity of Guadalajara, Health Sciences University Center, Department of Physiology, Researcher of Neurophysiology Laboratory, Guadalajara, MexicoAhvaz Jundishapur University of Medical Sciences, Faculty of Medicine, Department of Medical Parasitology, Ahvaz, Iran; Corresponding author.Introduction: The global protozoan parasite, Toxoplasma gondii, infects many warm-blooded animals and humans by employing different transmission routes. There have been some recent studies on the probable relevance of infectious agents and diabetes. Therefore, we conducted a systematic review and meta-analysis to identify the possible association between chronic toxoplasmosis and diabetes mellitus. Methods: This study was conducted following the general methodology recommended for systematic reviews and meta-analysis. Nine English literature databases (Google scholar, PubMed, Scopus, Web of science, Science Direct, Ovid, ProQuest, IngentaConnect, and Wiley Online Library) were searched, up to January 2016. Random effects model was used to determine odds ratios and their 95% confidence intervals. Results: Our review resulted in a total of seven publications meeting the inclusion criteria. Because of significant heterogeneity, we estimated a common OR by a random effects model at 1.10 (95% CI = 0.13–9.57) with p = 0.929 and 2.39 (95% CI = 1.20–4.75) with p = 0.013 for type 1 and type 2 diabetes mellitus, respectively. Conclusion: Despite the limitations such as low number of studies, this meta-analysis suggests chronic toxoplasmosis as a possible risk factor for type 2 DM. However, based on random effects model no statistically significant association was observed between T. gondii and type 1 DM. It is highly recommended for researchers to carry out more accurate studies aiming to better understand this association. Keywords: Toxoplasma gondii, Diabetes mellitus, Systematic review, Meta-analysishttp://www.sciencedirect.com/science/article/pii/S1413867016303348 |
| spellingShingle | Hamidreza Majidiani Sahar Dalvand Ahmad Daryani Ma de la Luz Galvan-Ramirez Masoud Foroutan-Rad Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies Brazilian Journal of Infectious Diseases |
| title | Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies |
| title_full | Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies |
| title_fullStr | Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies |
| title_full_unstemmed | Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies |
| title_short | Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies |
| title_sort | is chronic toxoplasmosis a risk factor for diabetes mellitus a systematic review and meta analysis of case control studies |
| url | http://www.sciencedirect.com/science/article/pii/S1413867016303348 |
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