Intrinsically disordered proteins display no preference for chaperone binding in vivo.

Intrinsically disordered proteins display no preference for chaperone binding in vivo.

Intrinsically disordered/unstructured proteins (IDPs) are extremely sensitive to proteolysis in vitro, but show no enhanced degradation rates in vivo. Their existence and functioning may be explained if IDPs are preferentially associated with chaperones in the cell, which may offer protection agains...

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Bibliographic Details
Main Authors: Hedi Hegyi, Peter Tompa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2265518?pdf=render

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