Copy number analysis from whole-exome sequencing data revealed a novel homozygous deletion in PARK7 leads to severe early-onset Parkinson's disease

Copy number analysis from whole-exome sequencing data revealed a novel homozygous deletion in PARK7 leads to severe early-onset Parkinson's disease

Parkinson's disease (PD), a neurodegenerative disease characterized by both motor neuron and non-motor neuron symptoms, is the most frequent neurodegenerative disease after Alzheimer's disease. Both genetic and environmental factors take part in disease etiology. Most cases are considered...

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Bibliographic Details
Main Authors: Mohammad Reza Seyedtaghia, Mohammad Soudyab, Mohammad Shariati, Reza Jafarzadeh Esfehani, Shabnam Vafadar, Neda Shalaei, Vahid Nouri, Michael Zech, Julianne Winkelmann, Ali shoeibi, Ariane Sadr-Nabavi
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Parkinson's disease
WES
CNV
PARK7
Alu repeats
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023026002

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023026002

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