First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia
Small-diameter vascular substitutes remain necessary, especially in the absence of an available autologous vein. Using a completely autologous approach termed “in-body tissue architecture,” a small-diameter, long, tissue-engineered vascular graft, a “Biotube,” was developed. A below-the-knee distal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Journal of Vascular Surgery Cases and Innovative Techniques |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468428722001228 |
| _version_ | 1828110436652810240 |
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| author | Ryuji Higashita, MD, PhD Manami Miyazaki, MD Masaya Oi, MD, PhD Noboru Ishikawa, MD, PhD |
| author_facet | Ryuji Higashita, MD, PhD Manami Miyazaki, MD Masaya Oi, MD, PhD Noboru Ishikawa, MD, PhD |
| author_sort | Ryuji Higashita, MD, PhD |
| collection | DOAJ |
| description | Small-diameter vascular substitutes remain necessary, especially in the absence of an available autologous vein. Using a completely autologous approach termed “in-body tissue architecture,” a small-diameter, long, tissue-engineered vascular graft, a “Biotube,” was developed. A below-the-knee distal bypass using the Biotube as a composite with expanded polytetrafluoroethylene grafts was performed to treat a patient with chronic limb-threatening ischemia without a venous graft available. The wound on the foot had completely healed 3 months after the bypass surgery, and limb salvage and walking without claudication were achieved. At the 1-year postoperative follow-up examination, duplex ultrasound scans demonstrated graft patency without thrombus or stenosis. |
| first_indexed | 2024-04-11T11:19:06Z |
| format | Article |
| id | doaj.art-31a4b4ef0c13467e84d5816f9fe82ac8 |
| institution | Directory Open Access Journal |
| issn | 2468-4287 |
| language | English |
| last_indexed | 2024-04-11T11:19:06Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Vascular Surgery Cases and Innovative Techniques |
| spelling | doaj.art-31a4b4ef0c13467e84d5816f9fe82ac82022-12-22T04:27:07ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872022-09-0183488493First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemiaRyuji Higashita, MD, PhD0Manami Miyazaki, MD1Masaya Oi, MD, PhD2Noboru Ishikawa, MD, PhD3Department of Cardiovascular Surgery, Yokohama General Hospital, Yokohama, Japan; Correspondence: Ryuji Higashita, MD, PhD, Department of Cardiovascular Surgery, Yokohama General Hospital, 2201-5 Kurogane-cho, Aoba-ku, Yokohama 225-0025, JapanDepartment of Cardiovascular Surgery, Yokohama General Hospital, Yokohama, JapanDepartment of Cardiovascular Surgery, Yokohama General Hospital, Yokohama, JapanDepartment of Cardiovascular Surgery, Sanai Memorial Hospital, Chiba, JapanSmall-diameter vascular substitutes remain necessary, especially in the absence of an available autologous vein. Using a completely autologous approach termed “in-body tissue architecture,” a small-diameter, long, tissue-engineered vascular graft, a “Biotube,” was developed. A below-the-knee distal bypass using the Biotube as a composite with expanded polytetrafluoroethylene grafts was performed to treat a patient with chronic limb-threatening ischemia without a venous graft available. The wound on the foot had completely healed 3 months after the bypass surgery, and limb salvage and walking without claudication were achieved. At the 1-year postoperative follow-up examination, duplex ultrasound scans demonstrated graft patency without thrombus or stenosis.http://www.sciencedirect.com/science/article/pii/S2468428722001228Chronic limb-threatening ischemiaIn-body tissue architectureSmall diameter vascular conduitPeripheral artery bypass surgeryTissue-engineered vascular graft |
| spellingShingle | Ryuji Higashita, MD, PhD Manami Miyazaki, MD Masaya Oi, MD, PhD Noboru Ishikawa, MD, PhD First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia Journal of Vascular Surgery Cases and Innovative Techniques Chronic limb-threatening ischemia In-body tissue architecture Small diameter vascular conduit Peripheral artery bypass surgery Tissue-engineered vascular graft |
| title | First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia |
| title_full | First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia |
| title_fullStr | First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia |
| title_full_unstemmed | First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia |
| title_short | First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft “Biotube” for application in distal bypass for chronic limb-threatening ischemia |
| title_sort | first in human results of an in body tissue architecture induced tissue engineered vascular graft biotube for application in distal bypass for chronic limb threatening ischemia |
| topic | Chronic limb-threatening ischemia In-body tissue architecture Small diameter vascular conduit Peripheral artery bypass surgery Tissue-engineered vascular graft |
| url | http://www.sciencedirect.com/science/article/pii/S2468428722001228 |
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