Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema
AIM:To investigate the clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema(DME). <p>METHODS:From June to December in 2014, after the diagnosis was confirmed by fundus examination, fundus fluorescein angiography(F...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-11-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2015/11/201511028.pdf |
| _version_ | 1819090432988020736 |
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| author | Guo-Peng Ding Guo-Long Ding Shu Lei Wu-Qiang Shan Gui-Jun Xie Xiao-Jü Ding |
| author_facet | Guo-Peng Ding Guo-Long Ding Shu Lei Wu-Qiang Shan Gui-Jun Xie Xiao-Jü Ding |
| author_sort | Guo-Peng Ding |
| collection | DOAJ |
| description | AIM:To investigate the clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema(DME). <p>METHODS:From June to December in 2014, after the diagnosis was confirmed by fundus examination, fundus fluorescein angiography(FFA)and optical coherence tomography(OCT), 64 patients(64 eyes)from department of ophthalmology in Baoji People's Hospital with DME were randomly divided into experiment group(32 cases)and control group(32 cases). The experiment group received 577nm micro-pulse laser combined with intravitreal injection of Conbercept. The control group was treated with 577nm micro-pulse laser. The best corrected visual acuity(BCVA)and central macular thickness(CMT)of two groups before and after treatments were compared. <p>RESULTS:The ANOVA for two-way repeated measures was used to analyze the data of BCVA and CMT between two groups. The results showed that the interaction between treatment effects and time effects in BCVA and CMT was significant(<i>F</i>=46.92,<i>P</i><0.01; <i>F</i>=60.231,<i>P</i><0.01), the main effect of the treatment were significant(<i>F</i>=12.16,<i>P</i><0.01; <i>F</i>=8.983,<i>P</i><0.01). There was significant difference on the effect between the two treatments, BCVA and CMT of experiment group were better than those of control group. The main time effect was statistically significant(<i>F</i>=116.14,<i>P</i><0.01; <i>F</i>=397.376,<i>P</i><0.01). The BCVA means increased with the treatment time, but the CMT means decreased. <p>CONCLUSION: Intravitreal injection of Conbercept combined with 577nm micropulse laser on the treatment of DME was much better on reducing macular edema and improving visual acuity than the micro-pulse treatment. |
| first_indexed | 2024-12-21T22:23:45Z |
| format | Article |
| id | doaj.art-31a4f9f28be64b55a7c1f1eae58062da |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-21T22:23:45Z |
| publishDate | 2015-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-31a4f9f28be64b55a7c1f1eae58062da2022-12-21T18:48:16ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-11-0115111942194410.3980/j.issn.1672-5123.2015.11.28Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edemaGuo-Peng Ding0Guo-Long Ding1Shu Lei2Wu-Qiang Shan3Gui-Jun Xie4Xiao-Jü Ding5Baoji Ophthalmologic Hospital, Department of Ophthalmology, Baoji People's Hospital,Baoji 721000,Shaanxi Province, ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061,Shaanxi Province, ChinaDepartment of Pharmacy, Maternal and Child Health Hospital of Baoji City, Baoji 721000,Shaanxi Province, ChinaBaoji Ophthalmologic Hospital, Department of Ophthalmology, Baoji People's Hospital,Baoji 721000,Shaanxi Province, ChinaBaoji Ophthalmologic Hospital, Department of Ophthalmology, Baoji People's Hospital,Baoji 721000,Shaanxi Province, ChinaBaoji Ophthalmologic Hospital, Department of Ophthalmology, Baoji People's Hospital,Baoji 721000,Shaanxi Province, ChinaAIM:To investigate the clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema(DME). <p>METHODS:From June to December in 2014, after the diagnosis was confirmed by fundus examination, fundus fluorescein angiography(FFA)and optical coherence tomography(OCT), 64 patients(64 eyes)from department of ophthalmology in Baoji People's Hospital with DME were randomly divided into experiment group(32 cases)and control group(32 cases). The experiment group received 577nm micro-pulse laser combined with intravitreal injection of Conbercept. The control group was treated with 577nm micro-pulse laser. The best corrected visual acuity(BCVA)and central macular thickness(CMT)of two groups before and after treatments were compared. <p>RESULTS:The ANOVA for two-way repeated measures was used to analyze the data of BCVA and CMT between two groups. The results showed that the interaction between treatment effects and time effects in BCVA and CMT was significant(<i>F</i>=46.92,<i>P</i><0.01; <i>F</i>=60.231,<i>P</i><0.01), the main effect of the treatment were significant(<i>F</i>=12.16,<i>P</i><0.01; <i>F</i>=8.983,<i>P</i><0.01). There was significant difference on the effect between the two treatments, BCVA and CMT of experiment group were better than those of control group. The main time effect was statistically significant(<i>F</i>=116.14,<i>P</i><0.01; <i>F</i>=397.376,<i>P</i><0.01). The BCVA means increased with the treatment time, but the CMT means decreased. <p>CONCLUSION: Intravitreal injection of Conbercept combined with 577nm micropulse laser on the treatment of DME was much better on reducing macular edema and improving visual acuity than the micro-pulse treatment.http://ies.ijo.cn/cn_publish/2015/11/201511028.pdfConberceptmicro-pulse lasercentral macular thicknessthe best corrected visual acuity |
| spellingShingle | Guo-Peng Ding Guo-Long Ding Shu Lei Wu-Qiang Shan Gui-Jun Xie Xiao-Jü Ding Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema Guoji Yanke Zazhi Conbercept micro-pulse laser central macular thickness the best corrected visual acuity |
| title | Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema |
| title_full | Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema |
| title_fullStr | Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema |
| title_full_unstemmed | Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema |
| title_short | Clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema |
| title_sort | clinical effect of conbercept intravitreal injection combined with 577nm micro pulse laser on the treatment of diabetic macular edema |
| topic | Conbercept micro-pulse laser central macular thickness the best corrected visual acuity |
| url | http://ies.ijo.cn/cn_publish/2015/11/201511028.pdf |
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