Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration
Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world. Persistent low back pain can seriously affect a patient’s quality of life and even lead to disability. Furthermore, the corresponding medic...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1058251/full |
| _version_ | 1798015018692771840 |
|---|---|
| author | Zongtai Liu Changfeng Fu |
| author_facet | Zongtai Liu Changfeng Fu |
| author_sort | Zongtai Liu |
| collection | DOAJ |
| description | Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world. Persistent low back pain can seriously affect a patient’s quality of life and even lead to disability. Furthermore, the corresponding medical expenses create a serious economic burden to both individuals and society. Intervertebral disc degeneration is commonly thought to be related to age, injury, obesity, genetic susceptibility, and other risk factors. Nonetheless, its specific pathological process has not been completely elucidated; the current mainstream view considers that this condition arises from the interaction of multiple mechanisms. With the development of medical concepts and technology, clinicians and scientists tend to intervene in the early or middle stages of intervertebral disc degeneration to avoid further aggravation. However, with the aid of modern delivery systems, it is now possible to intervene in the process of intervertebral disc at the cellular and molecular levels. This review aims to provide an overview of the main mechanisms associated with intervertebral disc degeneration and the delivery systems that can help us to improve the efficacy of intervertebral disc degeneration treatment. |
| first_indexed | 2024-04-11T15:27:41Z |
| format | Article |
| id | doaj.art-31a518afd562473587d7eaa2c88b02e6 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T15:27:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-31a518afd562473587d7eaa2c88b02e62022-12-22T04:16:13ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10582511058251Application of single and cooperative different delivery systems for the treatment of intervertebral disc degenerationZongtai Liu0Changfeng Fu1Department of Orthopedics, Affiliated Hospital of Beihua University, Jilin, ChinaDepartment of Spine Surgery, First Hospital of Jilin University, Changchun, ChinaIntervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world. Persistent low back pain can seriously affect a patient’s quality of life and even lead to disability. Furthermore, the corresponding medical expenses create a serious economic burden to both individuals and society. Intervertebral disc degeneration is commonly thought to be related to age, injury, obesity, genetic susceptibility, and other risk factors. Nonetheless, its specific pathological process has not been completely elucidated; the current mainstream view considers that this condition arises from the interaction of multiple mechanisms. With the development of medical concepts and technology, clinicians and scientists tend to intervene in the early or middle stages of intervertebral disc degeneration to avoid further aggravation. However, with the aid of modern delivery systems, it is now possible to intervene in the process of intervertebral disc at the cellular and molecular levels. This review aims to provide an overview of the main mechanisms associated with intervertebral disc degeneration and the delivery systems that can help us to improve the efficacy of intervertebral disc degeneration treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1058251/fulldelivery systemintervertebral disc degenerationbiomaterialnanometer materialslow back pain |
| spellingShingle | Zongtai Liu Changfeng Fu Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration Frontiers in Bioengineering and Biotechnology delivery system intervertebral disc degeneration biomaterial nanometer materials low back pain |
| title | Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| title_full | Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| title_fullStr | Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| title_full_unstemmed | Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| title_short | Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| title_sort | application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration |
| topic | delivery system intervertebral disc degeneration biomaterial nanometer materials low back pain |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1058251/full |
| work_keys_str_mv | AT zongtailiu applicationofsingleandcooperativedifferentdeliverysystemsforthetreatmentofintervertebraldiscdegeneration AT changfengfu applicationofsingleandcooperativedifferentdeliverysystemsforthetreatmentofintervertebraldiscdegeneration |