Serum and 24-hour urinary tests cost-effectiveness in stone formers
Abstract Objective To assess the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. Methods This study analyzes the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney st...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01310-w |
| _version_ | 1797556147653181440 |
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| author | Abdolreza Mohammadi Hiro Farabi Leila Zareian Baghdadabad Behzad Narouie Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir |
| author_facet | Abdolreza Mohammadi Hiro Farabi Leila Zareian Baghdadabad Behzad Narouie Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir |
| author_sort | Abdolreza Mohammadi |
| collection | DOAJ |
| description | Abstract Objective To assess the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. Methods This study analyzes the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. The sensitivity and specificity, false positive, and negative results of the tests are extracted from diagnostic kits used in the laboratories of the target community. To accurately infer the results, a simulation based on 1000 people was used through 22 standard laboratory tests (Additional File 2), including calcium, oxalate, phosphate, uric acid, sulfate, potassium, sodium, citrate, and magnesium in 24-hour urine; and calcium, creatinine, Vit D, uric acid, and intact parathyroid hormone (PTH) in serum. The incremental cost-effectiveness ratio (ICER) was calculated and compared for each diagnostic test versus other diagnostic tests according to the incremental cost required for correct diagnoses of stone causes. Results Urinary uric acid, citrate, and serum potassium constitute the cost-effectiveness boundary curve in this study. This means that other diagnostic tests are not cost-effective compared to these three tests in terms of indexing at least one item of cost and effectiveness. The ICER index for each correct diagnosis with the urinary uric acid test was $ 1.25 per diagnosis, the most cost-effective test compared to serum potassium and urinary citrate. Conclusion The simplified blood and 24-hour urine metabolic evaluation, including urinary uric acid, citrate, and serum potassium, constitute the cost-effectiveness boundary curve. The most cost-effective test was urinary uric acid measurement. |
| first_indexed | 2024-03-10T16:57:42Z |
| format | Article |
| id | doaj.art-31a5e97556fd4ab1a89bac1cdf78024f |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-10T16:57:42Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-31a5e97556fd4ab1a89bac1cdf78024f2023-11-20T11:03:34ZengBMCBMC Urology1471-24902023-08-012311810.1186/s12894-023-01310-wSerum and 24-hour urinary tests cost-effectiveness in stone formersAbdolreza Mohammadi0Hiro Farabi1Leila Zareian Baghdadabad2Behzad Narouie3Leonardo Oliveira Reis4Seyed Mohammad Kazem Aghamir5Urology Research Center, Tehran University of Medical SciencesCentre for Evaluation and Methods, Wolfson Institute of Population Health, Barts the London School of Medicine and Dentistry, Queen Mary University of LondonUrology Research Center, Tehran University of Medical SciencesDepartment of Urology, Zahedan University of Medical SciencesDepartment of Urology, UroScience, Unicamp and Pontifical, State University of Campinas, Catholic University of Campinas, PUC-CampinasUrology Research Center, Tehran University of Medical SciencesAbstract Objective To assess the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. Methods This study analyzes the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. The sensitivity and specificity, false positive, and negative results of the tests are extracted from diagnostic kits used in the laboratories of the target community. To accurately infer the results, a simulation based on 1000 people was used through 22 standard laboratory tests (Additional File 2), including calcium, oxalate, phosphate, uric acid, sulfate, potassium, sodium, citrate, and magnesium in 24-hour urine; and calcium, creatinine, Vit D, uric acid, and intact parathyroid hormone (PTH) in serum. The incremental cost-effectiveness ratio (ICER) was calculated and compared for each diagnostic test versus other diagnostic tests according to the incremental cost required for correct diagnoses of stone causes. Results Urinary uric acid, citrate, and serum potassium constitute the cost-effectiveness boundary curve in this study. This means that other diagnostic tests are not cost-effective compared to these three tests in terms of indexing at least one item of cost and effectiveness. The ICER index for each correct diagnosis with the urinary uric acid test was $ 1.25 per diagnosis, the most cost-effective test compared to serum potassium and urinary citrate. Conclusion The simplified blood and 24-hour urine metabolic evaluation, including urinary uric acid, citrate, and serum potassium, constitute the cost-effectiveness boundary curve. The most cost-effective test was urinary uric acid measurement.https://doi.org/10.1186/s12894-023-01310-wUrolithiasisMetabolic evaluationRecurrent kidney stone24-hour urinary testCost-effectiveness |
| spellingShingle | Abdolreza Mohammadi Hiro Farabi Leila Zareian Baghdadabad Behzad Narouie Leonardo Oliveira Reis Seyed Mohammad Kazem Aghamir Serum and 24-hour urinary tests cost-effectiveness in stone formers BMC Urology Urolithiasis Metabolic evaluation Recurrent kidney stone 24-hour urinary test Cost-effectiveness |
| title | Serum and 24-hour urinary tests cost-effectiveness in stone formers |
| title_full | Serum and 24-hour urinary tests cost-effectiveness in stone formers |
| title_fullStr | Serum and 24-hour urinary tests cost-effectiveness in stone formers |
| title_full_unstemmed | Serum and 24-hour urinary tests cost-effectiveness in stone formers |
| title_short | Serum and 24-hour urinary tests cost-effectiveness in stone formers |
| title_sort | serum and 24 hour urinary tests cost effectiveness in stone formers |
| topic | Urolithiasis Metabolic evaluation Recurrent kidney stone 24-hour urinary test Cost-effectiveness |
| url | https://doi.org/10.1186/s12894-023-01310-w |
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