INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT
Preoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article.Subjects .and .methods . 42 patients were included in this study, 18 received neoadjuvant chemoradiotherapy 5 × 5 Gy and 24 had chemo-radiotherapy up to 40 Gy in 4 Gy fractions.R...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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“ABV-press” Publishing house”, LLC
2015-02-01
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| Series: | Тазовая хирургия и онкология |
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| Online Access: | https://ok.abvpress.ru/jour/article/view/91 |
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| author | Yu. A. Barsukov A. G. Perevoshchikov D. V. Kuzmichev V. A. Аliyev A. G. Malikhov I. Sh. Tatayev S. S. Balyasnikova A. V. Polynovskiy |
| author_facet | Yu. A. Barsukov A. G. Perevoshchikov D. V. Kuzmichev V. A. Аliyev A. G. Malikhov I. Sh. Tatayev S. S. Balyasnikova A. V. Polynovskiy |
| author_sort | Yu. A. Barsukov |
| collection | DOAJ |
| description | Preoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article.Subjects .and .methods . 42 patients were included in this study, 18 received neoadjuvant chemoradiotherapy 5 × 5 Gy and 24 had chemo-radiotherapy up to 40 Gy in 4 Gy fractions.Results . Treatment had acceptable toxicity levels with grade III toxicity of 11.1 % and 8.3 % accordingly. 20.8 % had pathological complete response following 40 Gy chemoradiotherapy. 22.2 % patients in 5 × 5 Gy group had intershinctering resections comparing to 75 % patients in 40 Gy group. No local or distant recurrences were observed with a median followup of 42.9 months and 18.1 months accordingly.Conclusions . Developed treatment scheme have high efficacy, improving surgery ablastics and leading to good long-term outcome, improving sphincter preservation rate and patients quality of life. |
| first_indexed | 2024-03-12T18:10:09Z |
| format | Article |
| id | doaj.art-31a65796ad6e4214b1add5a1445e929f |
| institution | Directory Open Access Journal |
| issn | 2686-9594 |
| language | Russian |
| last_indexed | 2024-03-12T18:10:09Z |
| publishDate | 2015-02-01 |
| publisher | “ABV-press” Publishing house”, LLC |
| record_format | Article |
| series | Тазовая хирургия и онкология |
| spelling | doaj.art-31a65796ad6e4214b1add5a1445e929f2023-08-02T09:16:27Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942015-02-0104344110.17650/2220-3478-2013-0-4-34-4185INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENTYu. A. Barsukov0A. G. Perevoshchikov1D. V. Kuzmichev2V. A. Аliyev3A. G. Malikhov4I. Sh. Tatayev5S. S. Balyasnikova6A. V. Polynovskiy7N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowPreoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article.Subjects .and .methods . 42 patients were included in this study, 18 received neoadjuvant chemoradiotherapy 5 × 5 Gy and 24 had chemo-radiotherapy up to 40 Gy in 4 Gy fractions.Results . Treatment had acceptable toxicity levels with grade III toxicity of 11.1 % and 8.3 % accordingly. 20.8 % had pathological complete response following 40 Gy chemoradiotherapy. 22.2 % patients in 5 × 5 Gy group had intershinctering resections comparing to 75 % patients in 40 Gy group. No local or distant recurrences were observed with a median followup of 42.9 months and 18.1 months accordingly.Conclusions . Developed treatment scheme have high efficacy, improving surgery ablastics and leading to good long-term outcome, improving sphincter preservation rate and patients quality of life.https://ok.abvpress.ru/jour/article/view/91low rectal cancer involving anorectal regioncombined treatmentintersphincteric resections |
| spellingShingle | Yu. A. Barsukov A. G. Perevoshchikov D. V. Kuzmichev V. A. Аliyev A. G. Malikhov I. Sh. Tatayev S. S. Balyasnikova A. V. Polynovskiy INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT Тазовая хирургия и онкология low rectal cancer involving anorectal region combined treatment intersphincteric resections |
| title | INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT |
| title_full | INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT |
| title_fullStr | INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT |
| title_full_unstemmed | INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT |
| title_short | INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT |
| title_sort | intersphincteric resections for low rectal cancer with anorectal region involvement |
| topic | low rectal cancer involving anorectal region combined treatment intersphincteric resections |
| url | https://ok.abvpress.ru/jour/article/view/91 |
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