Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital
An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2006-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/12/5/05-0910_article |
| _version_ | 1819112315765653504 |
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| author | Armand Paauw Ad C. Fluit Jan Verhoef Maurine A. Leverstein-van Hall |
| author_facet | Armand Paauw Ad C. Fluit Jan Verhoef Maurine A. Leverstein-van Hall |
| author_sort | Armand Paauw |
| collection | DOAJ |
| description | An outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEΔ1, sul1, orf513, qnrA1, ampR, qacEΔ1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the blaCTX-M-9 extended-spectrum β-lactamase. |
| first_indexed | 2024-12-22T04:11:34Z |
| format | Article |
| id | doaj.art-31a879cda2674a2381103cac130478b2 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T04:11:34Z |
| publishDate | 2006-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-31a879cda2674a2381103cac130478b22022-12-21T18:39:30ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592006-05-0112580781210.3201/eid1205.050910Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch HospitalArmand PaauwAd C. FluitJan VerhoefMaurine A. Leverstein-van HallAn outbreak of Enterobacter cloacae infections with variable susceptibility to fluoroquinolones occurred in the University Medical Center Utrecht in the Netherlands in 2002. Our investigation showed that a qnrA1 gene was present in 78 (94%) of 83 outbreak isolates and that a qnrA1-encoding plasmid transferred to other strains of the same species and other species. The earliest isolate carrying this same plasmid was isolated in 1999. qnrA1 was located in a complex integron consisting of the intI1, aadB, qacEΔ1, sul1, orf513, qnrA1, ampR, qacEΔ1, and sul1 genes that were not described previously. On the same plasmid, 2 other class 1 integrons were present. One was a new integron associated with the blaCTX-M-9 extended-spectrum β-lactamase.https://wwwnc.cdc.gov/eid/article/12/5/05-0910_articleqnrAEnterobacter cloacaeintegronfluoroquinolonesplasmid-mediatedqnr |
| spellingShingle | Armand Paauw Ad C. Fluit Jan Verhoef Maurine A. Leverstein-van Hall Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital Emerging Infectious Diseases qnrA Enterobacter cloacae integron fluoroquinolones plasmid-mediated qnr |
| title | Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital |
| title_full | Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital |
| title_fullStr | Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital |
| title_full_unstemmed | Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital |
| title_short | Enterobacter cloacae Outbreak and Emergence of Quinolone Resistance Gene in Dutch Hospital |
| title_sort | enterobacter cloacae outbreak and emergence of quinolone resistance gene in dutch hospital |
| topic | qnrA Enterobacter cloacae integron fluoroquinolones plasmid-mediated qnr |
| url | https://wwwnc.cdc.gov/eid/article/12/5/05-0910_article |
| work_keys_str_mv | AT armandpaauw enterobactercloacaeoutbreakandemergenceofquinoloneresistancegeneindutchhospital AT adcfluit enterobactercloacaeoutbreakandemergenceofquinoloneresistancegeneindutchhospital AT janverhoef enterobactercloacaeoutbreakandemergenceofquinoloneresistancegeneindutchhospital AT maurinealeversteinvanhall enterobactercloacaeoutbreakandemergenceofquinoloneresistancegeneindutchhospital |