Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope
The vasoconstriction agent midodrine hydrochloride is a vital treatment for pediatric patients diagnosed with vasovagal syncope (VVS), although the efficacy is variable. This study was designed to explore the value of calcitonin gene-related peptide (CGRP) in predicting the effect of midodrine hydro...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1026539/full |
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| author | Lintian Li Huacai Zhao Xiuxiu Ma Fuyong Jiao Jing Lin |
| author_facet | Lintian Li Huacai Zhao Xiuxiu Ma Fuyong Jiao Jing Lin |
| author_sort | Lintian Li |
| collection | DOAJ |
| description | The vasoconstriction agent midodrine hydrochloride is a vital treatment for pediatric patients diagnosed with vasovagal syncope (VVS), although the efficacy is variable. This study was designed to explore the value of calcitonin gene-related peptide (CGRP) in predicting the effect of midodrine hydrochloride treatment upon VVS patients. In total, 55 children diagnosed with VVS were treated with midodrine hydrochloride for 3 months. Therapeutic response was evaluated using a symptom score system. CGRP levels were significantly higher in VVS patients (68.700 ± 6.460) than in control subjects (43.400 ± 5.810; t = 18.207, P < 0.001) and symptom scores correlated positively with CGRP concentrations (r = 0.779, P < 0.001). Patients treated with midodrine hydrochloride showed a significant reduction in symptom scores [4 (0, 6.5) vs. 1 (1, 2); z = –6.481; P < 0.001]. However, the value of plasma CGRP were potently elevated in the positive-response subjects than in the negative-response subjects (70.080 ± 5.040) vs. (61.150 ± 3.090); t = 5.817; P < 0.001). The area under the ROC curve showed that the value of CGRP for predicting the therapeutic response to midodrine hydrochloride was 0.946 (95% CI: 0.879–0.997, P < 0.001). With high sensitivity (97.7%) and specificity (83.3%), CGRP predicted the therapeutic response to midodrine hydrochloride (cut-off value, 62.56 pg/ml). In conclusion, CGRP can be used to predict the effect of midodrine hydrochloride administration in VVS patients. |
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| language | English |
| last_indexed | 2024-04-13T22:57:28Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-31a9145c40d9484ea23a05b4e2bd00f02022-12-22T02:25:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-10-011610.3389/fnins.2022.10265391026539Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncopeLintian Li0Huacai Zhao1Xiuxiu Ma2Fuyong Jiao3Jing Lin4School of Public Health, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Surgical, The Third Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, ChinaSchool of Public Health, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Pediatrics, The Third Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, ChinaKey Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Child and Adolescent Health Science Center, Xi’an Jiaotong University, Xi’an, ChinaThe vasoconstriction agent midodrine hydrochloride is a vital treatment for pediatric patients diagnosed with vasovagal syncope (VVS), although the efficacy is variable. This study was designed to explore the value of calcitonin gene-related peptide (CGRP) in predicting the effect of midodrine hydrochloride treatment upon VVS patients. In total, 55 children diagnosed with VVS were treated with midodrine hydrochloride for 3 months. Therapeutic response was evaluated using a symptom score system. CGRP levels were significantly higher in VVS patients (68.700 ± 6.460) than in control subjects (43.400 ± 5.810; t = 18.207, P < 0.001) and symptom scores correlated positively with CGRP concentrations (r = 0.779, P < 0.001). Patients treated with midodrine hydrochloride showed a significant reduction in symptom scores [4 (0, 6.5) vs. 1 (1, 2); z = –6.481; P < 0.001]. However, the value of plasma CGRP were potently elevated in the positive-response subjects than in the negative-response subjects (70.080 ± 5.040) vs. (61.150 ± 3.090); t = 5.817; P < 0.001). The area under the ROC curve showed that the value of CGRP for predicting the therapeutic response to midodrine hydrochloride was 0.946 (95% CI: 0.879–0.997, P < 0.001). With high sensitivity (97.7%) and specificity (83.3%), CGRP predicted the therapeutic response to midodrine hydrochloride (cut-off value, 62.56 pg/ml). In conclusion, CGRP can be used to predict the effect of midodrine hydrochloride administration in VVS patients.https://www.frontiersin.org/articles/10.3389/fnins.2022.1026539/fullvasovagal syncopemidodrine hydrochloridecalcitonin gene-related peptidechildhoodpredictive study |
| spellingShingle | Lintian Li Huacai Zhao Xiuxiu Ma Fuyong Jiao Jing Lin Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope Frontiers in Neuroscience vasovagal syncope midodrine hydrochloride calcitonin gene-related peptide childhood predictive study |
| title | Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| title_full | Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| title_fullStr | Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| title_full_unstemmed | Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| title_short | Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| title_sort | calcitonin gene related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope |
| topic | vasovagal syncope midodrine hydrochloride calcitonin gene-related peptide childhood predictive study |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1026539/full |
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