Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia
Eshetu Erjino, Ermias Abera, Lire Lemma Tirore Department of Public Health, College of Medicine and Health Sciences, Wachemo University, Hossana, Sothern EthiopiaCorrespondence: Lire Lemma Tirore, Email ganetlemma@gmail.comBackground: Unsuppressed viral load count in patients on anti-retroviral ther...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-04-01
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| Series: | HIV/AIDS: Research and Palliative Care |
| Subjects: | |
| Online Access: | https://www.dovepress.com/time-to-viral-load-suppression-and-its-predictors-among-adult-patients-peer-reviewed-fulltext-article-HIV |
| _version_ | 1797843363252142080 |
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| author | Erjino E Abera E Lemma Tirore L |
| author_facet | Erjino E Abera E Lemma Tirore L |
| author_sort | Erjino E |
| collection | DOAJ |
| description | Eshetu Erjino, Ermias Abera, Lire Lemma Tirore Department of Public Health, College of Medicine and Health Sciences, Wachemo University, Hossana, Sothern EthiopiaCorrespondence: Lire Lemma Tirore, Email ganetlemma@gmail.comBackground: Unsuppressed viral load count in patients on anti-retroviral therapy is linked to poorer survival and increased transmission of the virus. Despite efforts made in Ethiopia, the viral load suppression rate is still low.Objective: To estimate time to viral load suppression and predictors of viral load suppression among adults on anti-retroviral therapy in Nigist Elen Mohamed Memorial Comprehensive Specialized Hospital, 2022.Materials and Methods: A retrospective follow-up study was conducted among 297 adults on anti-retroviral therapy from January 1, 2016, to December 31, 2021. A simple random sampling technique was used to select study participants. The data were analyzed using STATA 14. Cox regression model was used. The adjusted hazard ratio with 95% CI was estimated.Results: A total of 296 records of patients on anti-retroviral therapy were included in this study. The incidence of viral load suppression was 9.68 per 100-person months. The median time for viral load suppression was 9 months. Patients with baseline CD4 ≥ 200 cell/mm3 (AHR: 1.87; 95% CI = 1.34, 2.63), who had no opportunistic infections (AHR = 1.84; 95% CI = 1.34, 2.52), who were on WHO clinical stage-I or II (AHR = 2.12; 95% CI = 1.18, 3.79) and who have taken tuberculosis preventive therapy (AHR = 2.24; 95% CI = 1.66, 3.02) had higher hazards of viral load suppression.Conclusion: The median time for viral load suppression was 9 months. Patients who had no opportunistic infection, with higher CD4 count, on WHO clinical stage-I or II, who have taken tuberculosis preventive therapy had higher hazards of viral load suppression. Careful monitoring and counseling of patients with CD4 levels lower than 200 cells/mm3 are necessary. Careful monitoring and counseling of patients in advanced WHO clinical stages, with lower CD4 count levels and with opportunistic infections is crucial. Strengthening the provision of tuberculosis preventive therapy is warranted.Keywords: anti-retroviral therapy, viral load suppression, predictor |
| first_indexed | 2024-04-09T17:05:08Z |
| format | Article |
| id | doaj.art-31a9adecb30245bd9aa6b1c6bfd1164a |
| institution | Directory Open Access Journal |
| issn | 1179-1373 |
| language | English |
| last_indexed | 2024-04-09T17:05:08Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | HIV/AIDS: Research and Palliative Care |
| spelling | doaj.art-31a9adecb30245bd9aa6b1c6bfd1164a2023-04-20T18:42:14ZengDove Medical PressHIV/AIDS: Research and Palliative Care1179-13732023-04-01Volume 1515717183170Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern EthiopiaErjino EAbera ELemma Tirore LEshetu Erjino, Ermias Abera, Lire Lemma Tirore Department of Public Health, College of Medicine and Health Sciences, Wachemo University, Hossana, Sothern EthiopiaCorrespondence: Lire Lemma Tirore, Email ganetlemma@gmail.comBackground: Unsuppressed viral load count in patients on anti-retroviral therapy is linked to poorer survival and increased transmission of the virus. Despite efforts made in Ethiopia, the viral load suppression rate is still low.Objective: To estimate time to viral load suppression and predictors of viral load suppression among adults on anti-retroviral therapy in Nigist Elen Mohamed Memorial Comprehensive Specialized Hospital, 2022.Materials and Methods: A retrospective follow-up study was conducted among 297 adults on anti-retroviral therapy from January 1, 2016, to December 31, 2021. A simple random sampling technique was used to select study participants. The data were analyzed using STATA 14. Cox regression model was used. The adjusted hazard ratio with 95% CI was estimated.Results: A total of 296 records of patients on anti-retroviral therapy were included in this study. The incidence of viral load suppression was 9.68 per 100-person months. The median time for viral load suppression was 9 months. Patients with baseline CD4 ≥ 200 cell/mm3 (AHR: 1.87; 95% CI = 1.34, 2.63), who had no opportunistic infections (AHR = 1.84; 95% CI = 1.34, 2.52), who were on WHO clinical stage-I or II (AHR = 2.12; 95% CI = 1.18, 3.79) and who have taken tuberculosis preventive therapy (AHR = 2.24; 95% CI = 1.66, 3.02) had higher hazards of viral load suppression.Conclusion: The median time for viral load suppression was 9 months. Patients who had no opportunistic infection, with higher CD4 count, on WHO clinical stage-I or II, who have taken tuberculosis preventive therapy had higher hazards of viral load suppression. Careful monitoring and counseling of patients with CD4 levels lower than 200 cells/mm3 are necessary. Careful monitoring and counseling of patients in advanced WHO clinical stages, with lower CD4 count levels and with opportunistic infections is crucial. Strengthening the provision of tuberculosis preventive therapy is warranted.Keywords: anti-retroviral therapy, viral load suppression, predictorhttps://www.dovepress.com/time-to-viral-load-suppression-and-its-predictors-among-adult-patients-peer-reviewed-fulltext-article-HIVanti-retroviral therapyviral load suppressionpredictor |
| spellingShingle | Erjino E Abera E Lemma Tirore L Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia HIV/AIDS: Research and Palliative Care anti-retroviral therapy viral load suppression predictor |
| title | Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia |
| title_full | Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia |
| title_fullStr | Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia |
| title_full_unstemmed | Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia |
| title_short | Time to Viral Load Suppression and Its Predictors Among Adult Patients on Antiretro Viral Therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, Southern Ethiopia |
| title_sort | time to viral load suppression and its predictors among adult patients on antiretro viral therapy in nigist eleni mohammed memorial comprehensive specialized hospital hossana southern ethiopia |
| topic | anti-retroviral therapy viral load suppression predictor |
| url | https://www.dovepress.com/time-to-viral-load-suppression-and-its-predictors-among-adult-patients-peer-reviewed-fulltext-article-HIV |
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