Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Summary: Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal lin...

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Bibliographic Details
Main Authors: Shalu Sharma, Ananda Kishore Mukherjee, Shuvra Shekhar Roy, Sulochana Bagri, Silje Lier, Meenakshi Verma, Antara Sengupta, Manish Kumar, Gaute Nesse, Deo Prakash Pandey, Shantanu Chowdhury
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
telomerase
telomere repeat binding factor
shelterin proteins
cancer
hTERT promoter mutations
G-quadruplexe
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004964

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