Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA
The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2023-02-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/29/2/22-0817_article |
| _version_ | 1797945107340591104 |
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| author | Dakai Liu Yexiao Cheng Hangyu Zhou Lulan Wang Roberto Hurtado Fiel Yehudah Gruenstein Jean Jingzi Luo Vishnu Singh Eric Konadu Keither James Calvin Lui Pengcheng Gao Carl Urban Nishant Prasad Sorana Segal-Maurer Esther Wurzberger Genhong Cheng Aiping Wu William Harry Rodgers |
| author_facet | Dakai Liu Yexiao Cheng Hangyu Zhou Lulan Wang Roberto Hurtado Fiel Yehudah Gruenstein Jean Jingzi Luo Vishnu Singh Eric Konadu Keither James Calvin Lui Pengcheng Gao Carl Urban Nishant Prasad Sorana Segal-Maurer Esther Wurzberger Genhong Cheng Aiping Wu William Harry Rodgers |
| author_sort | Dakai Liu |
| collection | DOAJ |
| description |
The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission of the Omicron variant in the city of New York, we created a comprehensive genomic and epidemiologic analysis of 392 Omicron virus specimens collected during November 25–December 11, 2021. We found evidence of 4 independent introductions of Omicron subclades, including the Omicron subclade BA.1.1 with defining substitution of R346K in the spike protein. The continuous genetic divergence within each Omicron subclade revealed their local community transmission and co-circulation in New York, including both household and workplace transmissions supported by epidemiologic evidence. Our study highlights the urgent need for enhanced genomic surveillance and effective response planning for better prevention and management of emerging SARS-CoV-2 variants.
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| first_indexed | 2024-04-10T20:48:53Z |
| format | Article |
| id | doaj.art-31ab17d81cfc401c8d54945e6918ee56 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-10T20:48:53Z |
| publishDate | 2023-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-31ab17d81cfc401c8d54945e6918ee562023-01-23T18:21:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-02-0129237138010.3201/eid2902.220817Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USADakai LiuYexiao ChengHangyu ZhouLulan WangRoberto Hurtado FielYehudah GruensteinJean Jingzi LuoVishnu SinghEric KonaduKeither JamesCalvin LuiPengcheng GaoCarl UrbanNishant PrasadSorana Segal-MaurerEsther WurzbergerGenhong ChengAiping WuWilliam Harry Rodgers The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission of the Omicron variant in the city of New York, we created a comprehensive genomic and epidemiologic analysis of 392 Omicron virus specimens collected during November 25–December 11, 2021. We found evidence of 4 independent introductions of Omicron subclades, including the Omicron subclade BA.1.1 with defining substitution of R346K in the spike protein. The continuous genetic divergence within each Omicron subclade revealed their local community transmission and co-circulation in New York, including both household and workplace transmissions supported by epidemiologic evidence. Our study highlights the urgent need for enhanced genomic surveillance and effective response planning for better prevention and management of emerging SARS-CoV-2 variants. https://wwwnc.cdc.gov/eid/article/29/2/22-0817_articleCOVID-19SARS-CoV-2Omicronsubclade multiple introductionsco-circulationcommunity transmission |
| spellingShingle | Dakai Liu Yexiao Cheng Hangyu Zhou Lulan Wang Roberto Hurtado Fiel Yehudah Gruenstein Jean Jingzi Luo Vishnu Singh Eric Konadu Keither James Calvin Lui Pengcheng Gao Carl Urban Nishant Prasad Sorana Segal-Maurer Esther Wurzberger Genhong Cheng Aiping Wu William Harry Rodgers Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA Emerging Infectious Diseases COVID-19 SARS-CoV-2 Omicron subclade multiple introductions co-circulation community transmission |
| title | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
| title_full | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
| title_fullStr | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
| title_full_unstemmed | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
| title_short | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
| title_sort | early introduction and community transmission of sars cov 2 omicron variant new york new york usa |
| topic | COVID-19 SARS-CoV-2 Omicron subclade multiple introductions co-circulation community transmission |
| url | https://wwwnc.cdc.gov/eid/article/29/2/22-0817_article |
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