Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apop...
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10965 |
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| author | Se Hyo Jeong Hun Hwan Kim Sang Eun Ha Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Kwang Il Park Jeong Doo Heo Hyun Wook Kim Gon Sup Kim |
| author_facet | Se Hyo Jeong Hun Hwan Kim Sang Eun Ha Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Kwang Il Park Jeong Doo Heo Hyun Wook Kim Gon Sup Kim |
| author_sort | Se Hyo Jeong |
| collection | DOAJ |
| description | Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apoptosis in cancer cells. Flavonoids are non-artificial natural bioactive compounds that are gaining attention as being capable of for inducing apoptosis in cancer cells. Among these, in this study, we focus on flavones. Flavones are a subclass of the numerous available flavonoids and possess several bioactive functions. Some of the most reported and well-known critical flavones, namely apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin, are discussed in depth in this review. Our main aim is to investigate the effects of the selected flavones on apoptosis and cell signaling pathways that contribute to death due to various types of cancers. |
| first_indexed | 2024-03-09T23:41:39Z |
| format | Article |
| id | doaj.art-31b259fb5f29406f8cea103e5da8eb44 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:41:39Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-31b259fb5f29406f8cea103e5da8eb442023-11-23T16:51:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181096510.3390/ijms231810965Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in CancerSe Hyo Jeong0Hun Hwan Kim1Sang Eun Ha2Min Young Park3Pritam Bhagwan Bhosale4Abuyaseer Abusaliya5Kwang Il Park6Jeong Doo Heo7Hyun Wook Kim8Gon Sup Kim9Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaBiological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, KoreaDivision of Animal Bioscience and Intergrated Biotechnology, Jinju 52725, KoreaResearch Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, KoreaCancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apoptosis in cancer cells. Flavonoids are non-artificial natural bioactive compounds that are gaining attention as being capable of for inducing apoptosis in cancer cells. Among these, in this study, we focus on flavones. Flavones are a subclass of the numerous available flavonoids and possess several bioactive functions. Some of the most reported and well-known critical flavones, namely apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin, are discussed in depth in this review. Our main aim is to investigate the effects of the selected flavones on apoptosis and cell signaling pathways that contribute to death due to various types of cancers.https://www.mdpi.com/1422-0067/23/18/10965canceranticancerapoptosisflavonoidsflavonescell signaling pathway |
| spellingShingle | Se Hyo Jeong Hun Hwan Kim Sang Eun Ha Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Kwang Il Park Jeong Doo Heo Hyun Wook Kim Gon Sup Kim Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer International Journal of Molecular Sciences cancer anticancer apoptosis flavonoids flavones cell signaling pathway |
| title | Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer |
| title_full | Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer |
| title_fullStr | Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer |
| title_full_unstemmed | Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer |
| title_short | Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer |
| title_sort | flavones six selected flavones and their related signaling pathways that induce apoptosis in cancer |
| topic | cancer anticancer apoptosis flavonoids flavones cell signaling pathway |
| url | https://www.mdpi.com/1422-0067/23/18/10965 |
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