Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
The biosynthesis of pyridine rings is still poorly understood. Here the authors propose a biosynthetic pathway for pyridine-containing rubrolones, which is characterized by a non-enzymatic condensation and cyclization of the pyridine moiety.
Main Authors: | Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo, Geoffrey P. Horsman, Sheng-Xiong Huang |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms13083 |
Similar Items
-
Two new tropolonic alkaloids from Colchicum speciosum Steven bulbs
by: S. Tayyeb*, et al.
Published: (2017-11-01) -
Dihydroisatropolone C from <i>Streptomyces</i> and Its Implication in Tropolone-Ring Construction for Isatropolone Biosynthesis
by: Jiachang Liu, et al.
Published: (2022-04-01) -
Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
by: Jian-Ping Huang, et al.
Published: (2019-09-01) -
Advances on the biosynthesis of pyridine rings
by: Carolina E. Portero, et al.
Published: (2023-06-01) -
Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids
by: Lei Li, et al.
Published: (2022-08-01)