Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000600009&lng=en&tlng=en |
| _version_ | 1819229321785507840 |
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| author | Maria Stella Figueiredo Perla Vicari Eliza Yuriko Sugano Kimura Sandra Vallin Antunes Mihoko Yamamoto |
| author_facet | Maria Stella Figueiredo Perla Vicari Eliza Yuriko Sugano Kimura Sandra Vallin Antunes Mihoko Yamamoto |
| author_sort | Maria Stella Figueiredo |
| collection | DOAJ |
| description | CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin. |
| first_indexed | 2024-12-23T11:11:19Z |
| format | Article |
| id | doaj.art-31b78d3a807d4573b0cb86ca656aa3c4 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-23T11:11:19Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-31b78d3a807d4573b0cb86ca656aa3c42022-12-21T17:49:21ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460122627327510.1590/S1516-31802004000600009S1516-31802004000600009Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemiaMaria Stella Figueiredo0Perla Vicari1Eliza Yuriko Sugano Kimura2Sandra Vallin Antunes3Mihoko Yamamoto4Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloCONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000600009&lng=en&tlng=enHemoglobin HDiseaseAplastic anemiaMyeloid leukemiaMyelodysplastic syndromes |
| spellingShingle | Maria Stella Figueiredo Perla Vicari Eliza Yuriko Sugano Kimura Sandra Vallin Antunes Mihoko Yamamoto Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia São Paulo Medical Journal Hemoglobin H Disease Aplastic anemia Myeloid leukemia Myelodysplastic syndromes |
| title | Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| title_full | Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| title_fullStr | Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| title_full_unstemmed | Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| title_short | Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| title_sort | acquired hemoglobin h disease in a patient with aplastic anemia evolving into acute myeloid leukemia |
| topic | Hemoglobin H Disease Aplastic anemia Myeloid leukemia Myelodysplastic syndromes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000600009&lng=en&tlng=en |
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