Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis
BackgroundTriple negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with a poor prognosis due to its extremely aggressive nature and lack of effective treatment options. This study aims to summarize the current hotspots of TNBC research and evaluate the TNBC research trend...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.689553/full |
| _version_ | 1811306919283916800 |
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| author | Kai-jun Hao Xiao Jia Wen-ting Dai Ze-min Huo Hua-qiang Zhang Jing-wei Liu Xiao-bing Wang |
| author_facet | Kai-jun Hao Xiao Jia Wen-ting Dai Ze-min Huo Hua-qiang Zhang Jing-wei Liu Xiao-bing Wang |
| author_sort | Kai-jun Hao |
| collection | DOAJ |
| description | BackgroundTriple negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with a poor prognosis due to its extremely aggressive nature and lack of effective treatment options. This study aims to summarize the current hotspots of TNBC research and evaluate the TNBC research trends, both qualitatively and quantitatively.MethodsScientific publications of TNBC-related studies from January 1, 2010 to October 17, 2020 were obtained from the Web of Science database. The BICOMB software was used to obtain the high-frequency keywords layout. The gCLUTO was used to produce a biclustering analysis on the binary matrix of word-paper. The co-occurrence and collaboration analysis between authors, countries, institutions, and keywords were performed by VOSviewer software. Keyword burst detection was performed by CiteSpace.ResultsA total of 12,429 articles related to TNBC were identified. During 2010-2020, the most productive country/region and institution in TNBC field was the USA and The University of Texas MD Anderson Cancer Center, respectively. Cancer Research, Journal of Clinical Oncology, and Annals of Oncology were the first three periodicals with maximum publications in TNBC research. Eight research hotspots of TNBC were identified by co-word analysis. In the core hotspots, research on neoadjuvant chemotherapy, paclitaxel therapy, and molecular typing of TNBC is relatively mature. Research on immunotherapy and PARP inhibitor for TNBC is not yet mature but is the current focus of this field. Burst detection of keywords showed that studies on TNBC proteins and receptors, immunotherapy, target, and tumor cell migration showed bursts in recent three years.ConclusionThe current study revealed that TNBC studies are growing. Attention should be paid to the latest hotspots, such as immunotherapy, PARP inhibitors, target, and TNBC proteins and receptors. |
| first_indexed | 2024-04-13T08:54:14Z |
| format | Article |
| id | doaj.art-31baf204538c4f5ea9b4e6cb02137ab8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T08:54:14Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-31baf204538c4f5ea9b4e6cb02137ab82022-12-22T02:53:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-01-011110.3389/fonc.2021.689553689553Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric AnalysisKai-jun Hao0Xiao Jia1Wen-ting Dai2Ze-min Huo3Hua-qiang Zhang4Jing-wei Liu5Xiao-bing Wang6Department of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaBackgroundTriple negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with a poor prognosis due to its extremely aggressive nature and lack of effective treatment options. This study aims to summarize the current hotspots of TNBC research and evaluate the TNBC research trends, both qualitatively and quantitatively.MethodsScientific publications of TNBC-related studies from January 1, 2010 to October 17, 2020 were obtained from the Web of Science database. The BICOMB software was used to obtain the high-frequency keywords layout. The gCLUTO was used to produce a biclustering analysis on the binary matrix of word-paper. The co-occurrence and collaboration analysis between authors, countries, institutions, and keywords were performed by VOSviewer software. Keyword burst detection was performed by CiteSpace.ResultsA total of 12,429 articles related to TNBC were identified. During 2010-2020, the most productive country/region and institution in TNBC field was the USA and The University of Texas MD Anderson Cancer Center, respectively. Cancer Research, Journal of Clinical Oncology, and Annals of Oncology were the first three periodicals with maximum publications in TNBC research. Eight research hotspots of TNBC were identified by co-word analysis. In the core hotspots, research on neoadjuvant chemotherapy, paclitaxel therapy, and molecular typing of TNBC is relatively mature. Research on immunotherapy and PARP inhibitor for TNBC is not yet mature but is the current focus of this field. Burst detection of keywords showed that studies on TNBC proteins and receptors, immunotherapy, target, and tumor cell migration showed bursts in recent three years.ConclusionThe current study revealed that TNBC studies are growing. Attention should be paid to the latest hotspots, such as immunotherapy, PARP inhibitors, target, and TNBC proteins and receptors.https://www.frontiersin.org/articles/10.3389/fonc.2021.689553/fulltriple negative breast cancerbibliometric analysisco-word analysisco-citation analysisresearch hotspots |
| spellingShingle | Kai-jun Hao Xiao Jia Wen-ting Dai Ze-min Huo Hua-qiang Zhang Jing-wei Liu Xiao-bing Wang Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis Frontiers in Oncology triple negative breast cancer bibliometric analysis co-word analysis co-citation analysis research hotspots |
| title | Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis |
| title_full | Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis |
| title_fullStr | Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis |
| title_full_unstemmed | Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis |
| title_short | Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis |
| title_sort | mapping intellectual structures and research hotspots of triple negative breast cancer a bibliometric analysis |
| topic | triple negative breast cancer bibliometric analysis co-word analysis co-citation analysis research hotspots |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.689553/full |
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