K-134, a phosphodiesterase 3 inhibitor, reduces vascular inflammation and hypoxia, and prevents rupture of experimental abdominal aortic aneurysms

K-134, a phosphodiesterase 3 inhibitor, reduces vascular inflammation and hypoxia, and prevents rupture of experimental abdominal aortic aneurysms

Objective: Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease, which frequently results in fatal rupture; however, no pharmacologic treatment exists to inhibit AAA growth and prevent rupture. In this study, we investigated whether K-134, a novel phosphodiesterase 3 inhibitor, could li...

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Bibliographic Details
Main Authors: Naoki Unno, MD, Hiroki Tanaka, MD, PhD, Tatsuro Yata, MD, PhD, Takafumi Kayama, MD, Yuta Yamanaka, MD, Hajime Tsuyuki, MD, Masaki Sano, MD, PhD, Kazunori Inuzuka, MD, PhD, Ena Naruse, CVT, Hiroya Takeuchi, MD, PhD
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:JVS - Vascular Science
Subjects:
Abdominal aortic aneurysm
Phosphodiesterase 3 inhibitor
Hypoxia
Atherosclerosis
K-134
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350320300262

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