Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions
A synthesis of anthracycline aglycone derivatives is described. The key step utilizes a powerful domino carbopalladation approach and subsequent ring closure. During this process two of the four rings of the anthracycline scaffold are formed. Differently substituted carbohydrates and dialkyne chains...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2013-10-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.9.258 |
| _version_ | 1819173068637995008 |
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| author | Markus Leibeling Daniel B. Werz |
| author_facet | Markus Leibeling Daniel B. Werz |
| author_sort | Markus Leibeling |
| collection | DOAJ |
| description | A synthesis of anthracycline aglycone derivatives is described. The key step utilizes a powerful domino carbopalladation approach and subsequent ring closure. During this process two of the four rings of the anthracycline scaffold are formed. Differently substituted carbohydrates and dialkyne chains serve as versatile and simple starting materials for the reaction sequence. Diverse building blocks lead to a variety of different products and a broad range of structural diversity. |
| first_indexed | 2024-12-22T20:17:12Z |
| format | Article |
| id | doaj.art-31bb63620fb54f219db4628f08139ec2 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-22T20:17:12Z |
| publishDate | 2013-10-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-31bb63620fb54f219db4628f08139ec22022-12-21T18:13:56ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-10-01912194220110.3762/bjoc.9.2581860-5397-9-258Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactionsMarkus Leibeling0Daniel B. Werz1Institut für Organische Chemie, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, GermanyInstitut für Organische Chemie, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, GermanyA synthesis of anthracycline aglycone derivatives is described. The key step utilizes a powerful domino carbopalladation approach and subsequent ring closure. During this process two of the four rings of the anthracycline scaffold are formed. Differently substituted carbohydrates and dialkyne chains serve as versatile and simple starting materials for the reaction sequence. Diverse building blocks lead to a variety of different products and a broad range of structural diversity.https://doi.org/10.3762/bjoc.9.258anthracyclinescarbohydratescarbopalladationcatalysisdomino reactionnatural products |
| spellingShingle | Markus Leibeling Daniel B. Werz Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions Beilstein Journal of Organic Chemistry anthracyclines carbohydrates carbopalladation catalysis domino reaction natural products |
| title | Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| title_full | Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| title_fullStr | Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| title_full_unstemmed | Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| title_short | Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| title_sort | flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions |
| topic | anthracyclines carbohydrates carbopalladation catalysis domino reaction natural products |
| url | https://doi.org/10.3762/bjoc.9.258 |
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