Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i>
Plants of the genus <i>Tylophora</i> have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones. Of the nearly 300 species reported in the <i>Tylophora</i> genus, eight are primarily used in var...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/5/1143 |
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| author | Ehab M. Mostafa Arafa Musa Hamdoon A. Mohammed Abdulaziz Ibrahim Alzarea Mohamed A. Abdelgawad Mohammad M. Al-Sanea Ahmed Ismail Ameeduzzafar Zafar Mohammed Elmowafy Samy Selim Riaz A. Khan |
| author_facet | Ehab M. Mostafa Arafa Musa Hamdoon A. Mohammed Abdulaziz Ibrahim Alzarea Mohamed A. Abdelgawad Mohammad M. Al-Sanea Ahmed Ismail Ameeduzzafar Zafar Mohammed Elmowafy Samy Selim Riaz A. Khan |
| author_sort | Ehab M. Mostafa |
| collection | DOAJ |
| description | Plants of the genus <i>Tylophora</i> have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones. Of the nearly 300 species reported in the <i>Tylophora</i> genus, eight are primarily used in various forms to treat a variety of bodily disorders based on the symptoms. Certain plants from the genus have found use as anti-inflammatory, anti-tumor, anti-allergic, anti-microbial, hypoglycemic, hypolipidemic, anti-oxidant, smooth muscle relaxant, immunomodulatory, and anti-plasmodium agents, as well as free-radical scavengers. Pharmacologically, a few plant species from the genus have exhibited broad-spectrum anti-microbial and anti-cancer activity, which has been proven through experimental evaluations. Some of the plants in the genus have also helped in alcohol-induced anxiety amelioration and myocardial damage repair. The plants belonging to the genus have also shown diuretic, anti-asthmatic, and hepato-protective activities. <i>Tylophora</i> plants have afforded diverse structural bases for secondary metabolites, mainly belonging to phenanthroindolizidine alkaloids, which have been found to treat several diseases with promising pharmacological activity levels. This review encompasses information on various <i>Tylophora</i> species, their distribution, corresponding plant synonyms, and chemical diversity of the secondary metabolic phytochemicals as reported in the literature, together with their prominent biological activities. |
| first_indexed | 2024-03-11T07:13:23Z |
| format | Article |
| id | doaj.art-31bb7aebe5e749d496516920f7b885a5 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T07:13:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-31bb7aebe5e749d496516920f7b885a52023-11-17T08:24:43ZengMDPI AGPlants2223-77472023-03-01125114310.3390/plants12051143Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i>Ehab M. Mostafa0Arafa Musa1Hamdoon A. Mohammed2Abdulaziz Ibrahim Alzarea3Mohamed A. Abdelgawad4Mohammad M. Al-Sanea5Ahmed Ismail6Ameeduzzafar Zafar7Mohammed Elmowafy8Samy Selim9Riaz A. Khan10Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaPharmacognosy Department, Faculty of Pharmacy, Fayoum University, Faiyum 63514, EgyptDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi ArabiaDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi ArabiaPlants of the genus <i>Tylophora</i> have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones. Of the nearly 300 species reported in the <i>Tylophora</i> genus, eight are primarily used in various forms to treat a variety of bodily disorders based on the symptoms. Certain plants from the genus have found use as anti-inflammatory, anti-tumor, anti-allergic, anti-microbial, hypoglycemic, hypolipidemic, anti-oxidant, smooth muscle relaxant, immunomodulatory, and anti-plasmodium agents, as well as free-radical scavengers. Pharmacologically, a few plant species from the genus have exhibited broad-spectrum anti-microbial and anti-cancer activity, which has been proven through experimental evaluations. Some of the plants in the genus have also helped in alcohol-induced anxiety amelioration and myocardial damage repair. The plants belonging to the genus have also shown diuretic, anti-asthmatic, and hepato-protective activities. <i>Tylophora</i> plants have afforded diverse structural bases for secondary metabolites, mainly belonging to phenanthroindolizidine alkaloids, which have been found to treat several diseases with promising pharmacological activity levels. This review encompasses information on various <i>Tylophora</i> species, their distribution, corresponding plant synonyms, and chemical diversity of the secondary metabolic phytochemicals as reported in the literature, together with their prominent biological activities.https://www.mdpi.com/2223-7747/12/5/1143genus <i>Tylophora</i>phenanthroindolizidine alkaloidschemotaxonomysecondary metabolitesanticancerantiviral |
| spellingShingle | Ehab M. Mostafa Arafa Musa Hamdoon A. Mohammed Abdulaziz Ibrahim Alzarea Mohamed A. Abdelgawad Mohammad M. Al-Sanea Ahmed Ismail Ameeduzzafar Zafar Mohammed Elmowafy Samy Selim Riaz A. Khan Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> Plants genus <i>Tylophora</i> phenanthroindolizidine alkaloids chemotaxonomy secondary metabolites anticancer antiviral |
| title | Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> |
| title_full | Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> |
| title_fullStr | Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> |
| title_full_unstemmed | Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> |
| title_short | Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus <i>Tylophora</i> |
| title_sort | phenanthroindolizidine alkaloids secondary metabolites diversity in medicinally viable plants of the genus i tylophora i |
| topic | genus <i>Tylophora</i> phenanthroindolizidine alkaloids chemotaxonomy secondary metabolites anticancer antiviral |
| url | https://www.mdpi.com/2223-7747/12/5/1143 |
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