Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol
Abstract Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that can cause joint pain and dysfunction, affecting the quality of life of patients. Nonsurgical treatment is the conventional treatment of KOA, among which physical therapy is widely used because of its simplicity,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-022-06074-2 |
| _version_ | 1797865818901446656 |
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| author | Xiao-yi Wang Chun-cha Bao Ran An Tao Wu Dun Wang Yu-jia Zhang Cheng-qi He |
| author_facet | Xiao-yi Wang Chun-cha Bao Ran An Tao Wu Dun Wang Yu-jia Zhang Cheng-qi He |
| author_sort | Xiao-yi Wang |
| collection | DOAJ |
| description | Abstract Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that can cause joint pain and dysfunction, affecting the quality of life of patients. Nonsurgical treatment is the conventional treatment of KOA, among which physical therapy is widely used because of its simplicity, convenience and effectiveness. The functional biomarker will add to the clinical fidelity and diagnostic accuracy. Therefore, our study chose a more objective evaluation indicator, functional near-infrared spectroscopy (fNIRS), to identify between healthy people and KOA patients, and to detect the pain change before and after treatment of KOA patients. Methods The study will be conducted in the Rehabilitation Medical Center of West China Hospital of Sichuan University and divided into 2 stages. In the first stage, we will compare and determine the differences in baseline data between healthy volunteers and KOA patients. In the second stage, 72 KOA patients will be randomly divided into two groups: the drug therapy group (DT) and the combination therapy group (CT) for 10 treatments. Outcome measures will be measured at baseline and on the 5th and 10th days after the intervention, including the numerical rating scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain catastrophizing scale (PCS), the association of pain severity with task-state functional connectivity fNIRS and association of pain severity with task-activated fNIRS. Discussion By analyzing the fNIRS data of healthy volunteers and KOA patients, our study will be determined whether fNIRS can be used as a new indicator to reflect the severity of pain in KOA patients. Subsequently, the same fNIRS data for KOA patients before and after the intervention will be collected to provide an accurate evaluation criterion for the effect of physical therapy on KOA. Trial registration The study was registered on the Chinese Registry website (registered in ChiCTR.org with the identifiers ChiCTR2200064175 and 29/09/2022). |
| first_indexed | 2024-04-09T23:15:08Z |
| format | Article |
| id | doaj.art-31bc7924157e4c62ad07d07a591b0213 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T23:15:08Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-31bc7924157e4c62ad07d07a591b02132023-03-22T10:03:13ZengBMCBMC Musculoskeletal Disorders1471-24742023-02-012411810.1186/s12891-022-06074-2Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocolXiao-yi Wang0Chun-cha Bao1Ran An2Tao Wu3Dun Wang4Yu-jia Zhang5Cheng-qi He6Department of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityAbstract Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that can cause joint pain and dysfunction, affecting the quality of life of patients. Nonsurgical treatment is the conventional treatment of KOA, among which physical therapy is widely used because of its simplicity, convenience and effectiveness. The functional biomarker will add to the clinical fidelity and diagnostic accuracy. Therefore, our study chose a more objective evaluation indicator, functional near-infrared spectroscopy (fNIRS), to identify between healthy people and KOA patients, and to detect the pain change before and after treatment of KOA patients. Methods The study will be conducted in the Rehabilitation Medical Center of West China Hospital of Sichuan University and divided into 2 stages. In the first stage, we will compare and determine the differences in baseline data between healthy volunteers and KOA patients. In the second stage, 72 KOA patients will be randomly divided into two groups: the drug therapy group (DT) and the combination therapy group (CT) for 10 treatments. Outcome measures will be measured at baseline and on the 5th and 10th days after the intervention, including the numerical rating scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain catastrophizing scale (PCS), the association of pain severity with task-state functional connectivity fNIRS and association of pain severity with task-activated fNIRS. Discussion By analyzing the fNIRS data of healthy volunteers and KOA patients, our study will be determined whether fNIRS can be used as a new indicator to reflect the severity of pain in KOA patients. Subsequently, the same fNIRS data for KOA patients before and after the intervention will be collected to provide an accurate evaluation criterion for the effect of physical therapy on KOA. Trial registration The study was registered on the Chinese Registry website (registered in ChiCTR.org with the identifiers ChiCTR2200064175 and 29/09/2022).https://doi.org/10.1186/s12891-022-06074-2Knee osteoarthritisRehabilitationPhysical therapyFunctional near-infrared spectroscopy |
| spellingShingle | Xiao-yi Wang Chun-cha Bao Ran An Tao Wu Dun Wang Yu-jia Zhang Cheng-qi He Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol BMC Musculoskeletal Disorders Knee osteoarthritis Rehabilitation Physical therapy Functional near-infrared spectroscopy |
| title | Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol |
| title_full | Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol |
| title_fullStr | Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol |
| title_full_unstemmed | Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol |
| title_short | Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol |
| title_sort | evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fnirs a randomized controlled trial protocol |
| topic | Knee osteoarthritis Rehabilitation Physical therapy Functional near-infrared spectroscopy |
| url | https://doi.org/10.1186/s12891-022-06074-2 |
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