Cell-Based Reporter System for High-Throughput Screening of MicroRNA Pathway Inhibitors and Its Limitations

Cell-Based Reporter System for High-Throughput Screening of MicroRNA Pathway Inhibitors and Its Limitations

MicroRNAs (miRNAs) are small RNAs repressing gene expression. They contribute to many physiological processes and pathologies. Consequently, strategies for manipulation of the miRNA pathway are of interest as they could provide tools for experimental or therapeutic interventions. One of such tools c...

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Bibliographic Details
Main Authors: Katerina Brustikova, David Sedlak, Jana Kubikova, Ctibor Skuta, Katerina Solcova, Radek Malik, Petr Bartunek, Petr Svoboda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Genetics
Subjects:
miRNA
high-throughput screening
let-7
miR-30
Argonaute
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00045/full

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