Comparison of local activation, functional connectivity, and structural connectivity in the N-back task
The N-back task is widely used to investigate working memory. Previous functional magnetic resonance imaging (fMRI) studies have shown that local brain activation depends on the difficulty of the N-back task. Recently, changes in functional connectivity and local activation during a task, such as a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1337976/full |
| _version_ | 1797271095455252480 |
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| author | Takatoshi Satake Takatoshi Satake Ai Taki Ai Taki Kazumi Kasahara Daisuke Yoshimaru Daisuke Yoshimaru Tomokazu Tsurugizawa Tomokazu Tsurugizawa |
| author_facet | Takatoshi Satake Takatoshi Satake Ai Taki Ai Taki Kazumi Kasahara Daisuke Yoshimaru Daisuke Yoshimaru Tomokazu Tsurugizawa Tomokazu Tsurugizawa |
| author_sort | Takatoshi Satake |
| collection | DOAJ |
| description | The N-back task is widely used to investigate working memory. Previous functional magnetic resonance imaging (fMRI) studies have shown that local brain activation depends on the difficulty of the N-back task. Recently, changes in functional connectivity and local activation during a task, such as a single-hand movement task, have been reported to give the distinct information. However, previous studies have not investigated functional connectivity changes in the entire brain during N-back tasks. In this study, we compared alterations in functional connectivity and local activation related to the difficulty of the N-back task. Because structural connectivity has been reported to be associated with local activation, we also investigated the relationship between structural connectivity and accuracy in a N-back task using diffusion tensor imaging (DTI). Changes in functional connectivity depend on the difficulty of the N-back task in a manner different from local activation, and the 2-back task is the best method for investigating working memory. This indicates that local activation and functional connectivity reflect different neuronal events during the N-back task. The top 10 structural connectivities associated with accuracy in the 2-back task were locally activated during the 2-back task. Therefore, structural connectivity as well as fMRI will be useful for predicting the accuracy of the 2-back task. |
| first_indexed | 2024-03-07T16:22:29Z |
| format | Article |
| id | doaj.art-31c055059c4c4f37930afe070218cdf6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-25T02:14:43Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-31c055059c4c4f37930afe070218cdf62024-03-07T10:00:27ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-03-011810.3389/fnins.2024.13379761337976Comparison of local activation, functional connectivity, and structural connectivity in the N-back taskTakatoshi Satake0Takatoshi Satake1Ai Taki2Ai Taki3Kazumi Kasahara4Daisuke Yoshimaru5Daisuke Yoshimaru6Tomokazu Tsurugizawa7Tomokazu Tsurugizawa8Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, JapanGraduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, JapanFaculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, JapanDivision of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, JapanHuman Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, JapanFaculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba, JapanThe N-back task is widely used to investigate working memory. Previous functional magnetic resonance imaging (fMRI) studies have shown that local brain activation depends on the difficulty of the N-back task. Recently, changes in functional connectivity and local activation during a task, such as a single-hand movement task, have been reported to give the distinct information. However, previous studies have not investigated functional connectivity changes in the entire brain during N-back tasks. In this study, we compared alterations in functional connectivity and local activation related to the difficulty of the N-back task. Because structural connectivity has been reported to be associated with local activation, we also investigated the relationship between structural connectivity and accuracy in a N-back task using diffusion tensor imaging (DTI). Changes in functional connectivity depend on the difficulty of the N-back task in a manner different from local activation, and the 2-back task is the best method for investigating working memory. This indicates that local activation and functional connectivity reflect different neuronal events during the N-back task. The top 10 structural connectivities associated with accuracy in the 2-back task were locally activated during the 2-back task. Therefore, structural connectivity as well as fMRI will be useful for predicting the accuracy of the 2-back task.https://www.frontiersin.org/articles/10.3389/fnins.2024.1337976/fullfunctional MRIdiffusion tensor imagingN-back taskstructural connectivitylocal activation |
| spellingShingle | Takatoshi Satake Takatoshi Satake Ai Taki Ai Taki Kazumi Kasahara Daisuke Yoshimaru Daisuke Yoshimaru Tomokazu Tsurugizawa Tomokazu Tsurugizawa Comparison of local activation, functional connectivity, and structural connectivity in the N-back task Frontiers in Neuroscience functional MRI diffusion tensor imaging N-back task structural connectivity local activation |
| title | Comparison of local activation, functional connectivity, and structural connectivity in the N-back task |
| title_full | Comparison of local activation, functional connectivity, and structural connectivity in the N-back task |
| title_fullStr | Comparison of local activation, functional connectivity, and structural connectivity in the N-back task |
| title_full_unstemmed | Comparison of local activation, functional connectivity, and structural connectivity in the N-back task |
| title_short | Comparison of local activation, functional connectivity, and structural connectivity in the N-back task |
| title_sort | comparison of local activation functional connectivity and structural connectivity in the n back task |
| topic | functional MRI diffusion tensor imaging N-back task structural connectivity local activation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1337976/full |
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