Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

Osteosarcoma is the most frequent and aggressive bone tumor in children and adolescents, with a long-term survival rate of 30%. Interleukin-12 (IL-12) is a potent cytokine that bridges innate and adaptive immunity, triggers antiangiogenic responses, and achieves potent antitumor effects. In this wor...

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Main Authors: Marta Zalacain, María Bunuales, Lucía Marrodan, Sara Labiano, Marisol Gonzalez-Huarriz, Naiara Martinez-Vélez, Virginia Laspidea, Montse Puigdelloses, Marc García-Moure, Manuela Gonzalez-Aparicio, Rubén Hernandez-Alcoceba, Marta M. Alonso, Ana Patiño-García
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
Pediatric solid tumors
therapy
osteosarcoma
high capacity adenoviral vectors
immunotherapy
IL-12
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301686

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