Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling
Sarcopenia is the loss of muscular mass and strength as a person ages, resulting in considerable impairment in daily functions and an increased risk of falls and fractures, finally leading to loss of independence. Coumestrol has been known to have an effect on the inhibition of skeletal muscle loss,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622004571 |
| _version_ | 1797956225306984448 |
|---|---|
| author | Young-Sool Hah Won Keong Lee Sangyeob Lee Jin-Hee Seo Eun Ji Kim Yeong-in Choe Sang Gon Kim Jun-Il Yoo |
| author_facet | Young-Sool Hah Won Keong Lee Sangyeob Lee Jin-Hee Seo Eun Ji Kim Yeong-in Choe Sang Gon Kim Jun-Il Yoo |
| author_sort | Young-Sool Hah |
| collection | DOAJ |
| description | Sarcopenia is the loss of muscular mass and strength as a person ages, resulting in considerable impairment in daily functions and an increased risk of falls and fractures, finally leading to loss of independence. Coumestrol has been known to have an effect on the inhibition of skeletal muscle loss, but the coumestrol protection mechanism is poorly understood. To investigate the protective effect of coumestrol against dexamethasone-induced muscle atrophy, in vitro and in vivo analysis was performed through dexamethasone-induced muscle atrophy mouse model and C2C12 myoblasts. As a results, coumestrol might attenuate the dexamethasone-induced muscle atrophy via blocking the ubiquitin–proteasome pathway induced by suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol would be a potential treatment agents for aging sarcopenia. |
| first_indexed | 2024-04-10T23:45:37Z |
| format | Article |
| id | doaj.art-31c57568ad7744a18ba0577772fd7ed6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T23:45:37Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-31c57568ad7744a18ba0577772fd7ed62023-01-11T04:28:19ZengElsevierJournal of Functional Foods1756-46462023-01-01100105387Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signalingYoung-Sool Hah0Won Keong Lee1Sangyeob Lee2Jin-Hee Seo3Eun Ji Kim4Yeong-in Choe5Sang Gon Kim6Jun-Il Yoo7Department of Orthopedics, Gyeongsang National University School of Medicine and Hospital, Institute of Health Sciences, Jinju, South Korea; Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South KoreaBiomedical Research Institute, Gyeongsang National University Hospital, Jinju, South KoreaBiomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea; Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju, South KoreaCrop Production Technology Research Division, National Institute of Crop Science, Rular Development Administration, Miryang, South KoreaDepartment of Orthopedics, Gyeongsang National University School of Medicine and Hospital, Institute of Health Sciences, Jinju, South KoreaDepartment of Orthopedics, Gyeongsang National University School of Medicine and Hospital, Institute of Health Sciences, Jinju, South KoreaAnti-Aging Research Group, Gyeongnam Oriental Anti-Aging Institute, Sancheong, South KoreaDepartment of Orthopedics, Gyeongsang National University School of Medicine and Hospital, Institute of Health Sciences, Jinju, South Korea; Corresponding author at: Department of Orthopaedic Surgery, Gyeongsang National University Hospital, 90 Chilamdong, Jinju, Gyeongnamdo 660-702, South Korea.Sarcopenia is the loss of muscular mass and strength as a person ages, resulting in considerable impairment in daily functions and an increased risk of falls and fractures, finally leading to loss of independence. Coumestrol has been known to have an effect on the inhibition of skeletal muscle loss, but the coumestrol protection mechanism is poorly understood. To investigate the protective effect of coumestrol against dexamethasone-induced muscle atrophy, in vitro and in vivo analysis was performed through dexamethasone-induced muscle atrophy mouse model and C2C12 myoblasts. As a results, coumestrol might attenuate the dexamethasone-induced muscle atrophy via blocking the ubiquitin–proteasome pathway induced by suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol would be a potential treatment agents for aging sarcopenia.http://www.sciencedirect.com/science/article/pii/S1756464622004571CoumestrolDexamethasoneMuscle atrophyFoxO1/3MuRF1MAFbx |
| spellingShingle | Young-Sool Hah Won Keong Lee Sangyeob Lee Jin-Hee Seo Eun Ji Kim Yeong-in Choe Sang Gon Kim Jun-Il Yoo Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling Journal of Functional Foods Coumestrol Dexamethasone Muscle atrophy FoxO1/3 MuRF1 MAFbx |
| title | Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling |
| title_full | Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling |
| title_fullStr | Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling |
| title_full_unstemmed | Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling |
| title_short | Coumestrol attenuates dexamethasone-induced muscle atrophy via AMPK-FOXO1/3 signaling |
| title_sort | coumestrol attenuates dexamethasone induced muscle atrophy via ampk foxo1 3 signaling |
| topic | Coumestrol Dexamethasone Muscle atrophy FoxO1/3 MuRF1 MAFbx |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622004571 |
| work_keys_str_mv | AT youngsoolhah coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT wonkeonglee coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT sangyeoblee coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT jinheeseo coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT eunjikim coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT yeonginchoe coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT sanggonkim coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling AT junilyoo coumestrolattenuatesdexamethasoneinducedmuscleatrophyviaampkfoxo13signaling |