Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy
Abstract Background Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield of sonosensitizers and tumor hypoxia are two vulnerable spots of SDT. Th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-022-01398-6 |
| _version_ | 1798041649521098752 |
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| author | Xiaohui Qiao Liyun Xue Hui Huang Xinyue Dai Yu Chen Hong Ding |
| author_facet | Xiaohui Qiao Liyun Xue Hui Huang Xinyue Dai Yu Chen Hong Ding |
| author_sort | Xiaohui Qiao |
| collection | DOAJ |
| description | Abstract Background Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield of sonosensitizers and tumor hypoxia are two vulnerable spots of SDT. Therefore, it is an advisable strategy to augment ROS level and simultaneously relieve hypoxia for SDT to arrive its full potential in cancer treatment. Results In this work, the defected two-dimensional (2D) Pd/H-TiO2 nanosheets (NSs) with triple antineoplastic properties were dexterously elaborated and engineered using a facile one-pot Pd-catalyzed hydrogenation tactic by loading a tiny amount of Pd and then inletting hydrogen flow at atmospheric pressure and temperature. The 2D black Pd/H-TiO2 NSs with oxygen defects exerted eximious SDT effect based on the decreased bandgap that made it easier for the separation of electrons and holes when triggered by ultrasound as theoretically guided by density functional theory calculations. Additionally, Pd/H-TiO2 NSs could serve as Fenton-like agents because of the presence of oxygen defects, facilitating the conversion of hydrogen peroxide into hydroxyl radicals for exerting the chemodynamic therapy (CDT). Simultaneously, the introduced tiny Pd component possessed catalase-like activity responsible for oxygen production to ameliorate hypoxic condition and thus contributed to improving SDT and CDT efficacies. Both in vitro and in vivo results provided compelling evidences of high ROS yield and aggrandized sono-chemodynamic effect of Pd/H-TiO2 nanosonosensitizers with the detailed underlying mechanism investigation by RNA sequencing. Conclusion This work delves the profound potential of Pd-catalyzed hydrogenated TiO2 on oncotherapy, and the effective antineoplastic performance and ignorable therapeutic toxicity make it a powerful competitor among a cornucopia of nanosonosensitizers. Graphical Abstract |
| first_indexed | 2024-04-11T22:24:29Z |
| format | Article |
| id | doaj.art-31c58a5b96364aeda54d7715b441167b |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:24:29Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-31c58a5b96364aeda54d7715b441167b2022-12-22T03:59:46ZengBMCJournal of Nanobiotechnology1477-31552022-04-0120111710.1186/s12951-022-01398-6Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapyXiaohui Qiao0Liyun Xue1Hui Huang2Xinyue Dai3Yu Chen4Hong Ding5Department of Ultrasound, Huashan Hospital, Fudan UniversityDepartment of Ultrasound, Huashan Hospital, Fudan UniversityShanghai Engineering Research Center of Organ Repair, Materdicine Lab, School of Life Sciences, Shanghai UniversityShanghai Engineering Research Center of Organ Repair, Materdicine Lab, School of Life Sciences, Shanghai UniversityShanghai Engineering Research Center of Organ Repair, Materdicine Lab, School of Life Sciences, Shanghai UniversityDepartment of Ultrasound, Huashan Hospital, Fudan UniversityAbstract Background Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield of sonosensitizers and tumor hypoxia are two vulnerable spots of SDT. Therefore, it is an advisable strategy to augment ROS level and simultaneously relieve hypoxia for SDT to arrive its full potential in cancer treatment. Results In this work, the defected two-dimensional (2D) Pd/H-TiO2 nanosheets (NSs) with triple antineoplastic properties were dexterously elaborated and engineered using a facile one-pot Pd-catalyzed hydrogenation tactic by loading a tiny amount of Pd and then inletting hydrogen flow at atmospheric pressure and temperature. The 2D black Pd/H-TiO2 NSs with oxygen defects exerted eximious SDT effect based on the decreased bandgap that made it easier for the separation of electrons and holes when triggered by ultrasound as theoretically guided by density functional theory calculations. Additionally, Pd/H-TiO2 NSs could serve as Fenton-like agents because of the presence of oxygen defects, facilitating the conversion of hydrogen peroxide into hydroxyl radicals for exerting the chemodynamic therapy (CDT). Simultaneously, the introduced tiny Pd component possessed catalase-like activity responsible for oxygen production to ameliorate hypoxic condition and thus contributed to improving SDT and CDT efficacies. Both in vitro and in vivo results provided compelling evidences of high ROS yield and aggrandized sono-chemodynamic effect of Pd/H-TiO2 nanosonosensitizers with the detailed underlying mechanism investigation by RNA sequencing. Conclusion This work delves the profound potential of Pd-catalyzed hydrogenated TiO2 on oncotherapy, and the effective antineoplastic performance and ignorable therapeutic toxicity make it a powerful competitor among a cornucopia of nanosonosensitizers. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01398-6Chemodynamic therapyNanozymeOxygen deficiencyPd/H-TiO2 nanosheetsSonodynamic therapy |
| spellingShingle | Xiaohui Qiao Liyun Xue Hui Huang Xinyue Dai Yu Chen Hong Ding Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy Journal of Nanobiotechnology Chemodynamic therapy Nanozyme Oxygen deficiency Pd/H-TiO2 nanosheets Sonodynamic therapy |
| title | Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy |
| title_full | Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy |
| title_fullStr | Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy |
| title_full_unstemmed | Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy |
| title_short | Engineering defected 2D Pd/H-TiO2 nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy |
| title_sort | engineering defected 2d pd h tio2 nanosonosensitizers for hypoxia alleviation and enhanced sono chemodynamic cancer nanotherapy |
| topic | Chemodynamic therapy Nanozyme Oxygen deficiency Pd/H-TiO2 nanosheets Sonodynamic therapy |
| url | https://doi.org/10.1186/s12951-022-01398-6 |
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